摘要
目的探讨黄体酮疗法治疗先兆流产对妊娠期合并症及围生儿结局的影响和作用机制。方法选取2013年1月至2014年1月自贡市第三人民医院收治的150例早期先兆流产产妇作为观察组,给予黄体酮治疗;以同期收治的150例健康妊娠女性作为对照组。比较两组产妇妊娠期合并症、围生儿结局及治疗前后血清孕酮、人孕激素诱导阻断因子(PIBF)水平等。结果两组产妇胎膜早破、胎盘早剥、胎盘前置、妊娠期高血压、妊娠期糖尿病及妊娠期胆汁淤积的妊娠期合并症发生率比较差异无统计学意义(P>0.05);两组分娩后1 min Apgar评分≤7分、难免流产、早产、活产儿、低体质量儿、巨大儿、胎儿窘迫及胎儿畸形的围生儿结局发生率比较差异无统计学意义(P>0.05)。观察组产妇治疗后血清孕酮水平[(87±14)nmol/L]显著高于对照组[(73±10)nmol/L]和治疗前[(77±11)nmol/L],差异有统计学意义(P<0.05);观察组产妇治疗前血清PIBF水平显著低于对照组[(316±71)nmol/L比(382±90)nmol/L](P<0.05),两组产妇治疗后血清PIBF水平显著高于治疗前,差异有统计学意义(P<0.05)。两组产妇治疗后PIBF水平比较差异无统计学意义(P>0.05)。结论黄体酮疗法治疗先兆流产可有效降低妊娠期合并症发生风险,并改善围生儿结局;而这一治疗作用与黄体酮上调血清PIBF水平密切相关。
Objective To investigate the influence and mechanism of progesterone therapy on pregnancy complication and perinatal outcomes in treatment of threatened abortion. Methods Total of 150 cases of threatened abortion treated with progesterone in Zigong City Third People＇s Hospital from Jan. 2013 to Jan. 2014 were included as observation group and 150 healthy pregnant women during the same period were chosen as control group. The pregnancy complications, perinatal outcomes and levels of serum progesterone and progesterone induced blocking factor（PIBF） of the two groups were compared before and after treatment. Results There was no significant difference in pregnancy complications including premature rupture of fetal membrane,placental abmption, placenta previa, gestational hypertension, gestational diabetes mellitus and intrahepatic cholestasis of pregnancy between the two groups （P 〉 0. 05 ）. There was no significant difference in perinatal outcomes including 1 rain Apgar score ≤ 7 scores, inevitable abortion, premature birth, live births,low birth weight,fetal macrosomia,fetal distress and fetal malformation of pregnancy between the two groups（P 〉0. 05 ）. The level of serum progesterone after treatment of the observation group was statistically significant higher than the control group and before treatment[ （87±14） nmol/L vs （73±10） nmol/L, （ 77±11 ） nmol/L] （P 〈 0. 05 ）. The levels of serum PIBF before treatment of the observation group was significantly lower than the control group[ （316±71 ） nmol/L vs （382±90） nmol/L] （P 〈0. 05）. The levels of semm PIBF after treatment of both groups were significantly higher than before treatment （P 〈 0. 05 ） ,but no significant different was observed between the two groups（P 〉 0.05 ）. Conclusion Progesterone therapy in treatment of threatened abortion can effectively reduce risk of pregnancy complication and improve perinatal outcomes, which is closely related to the upregulating serum P]BF function of progesterone.
出处
《医学综述》
2016年第2期356-358,共3页
Medical Recapitulate
关键词
先兆流产
黄体酮
围生儿结局
人孕激素诱导阻断因子
Threatened abortion
Progesterone
Perinatal outcomes
Progesterone induced blocking factor
