摘要
目的观察自拟固本养脏汤干预慢性阻塞性肺疾病急性加重期(AECOPD)肺动脉高压的疗效及其作用机理。方法将160例AECOPD伴肺动脉高压患者按1∶1原则随机分为治疗组与对照组,观察两组肺动脉高压、血液流变学指标、临床症状的变化,探讨固本养脏汤干预AECOPD肺动脉高压的疗效及机制。结果两组治疗后临床症状,血黏度及肺动脉高压较治疗前均有改善(P<0.05或P<0.01),但治疗组对其改善程度优于对照组(P<0.05或P<0.01)。结论固本养脏汤可能通过改善血液流变学状态,发挥降低AECOPD肺动脉高压及改善临床症状的作用,提高临床疗效。
Objective： To investigate curative effect and its mechanism of Guben Yangzang Tang on pulmonary hypertension in chronic obstructive pulmonary disease in acute aggravating period （AECOPD）. Methods： 160 cases with pulmonary hypertension with AECOPD were randomly divided into the treatment group and the control group in the principles of 1：1. Pulmonary hypertension,the change of hemorheology index and clinical symptoms of the two were observed. Guben Yangzang Tang curative effect and mechanism on pulmonary hypertension in AECOPD were detected. Results： After treatment,clinical symptoms,blood viscosity and pulmonary hypertension of both groups were improved （P〈 0.05 or P〈 0.01 ）, and the treatment group improved more than the control group （P〈 0.05 or P〈0.05）. Conlcusion： Guben Yangzang Tang can improve the clinical curative effect by changing the state of blood rheology, reduce AECOPD pulmonary hypertension and improve the clinical symptoms.
出处
《中国中医急症》
2016年第1期122-124,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
河北省中医药管理局科学研究计划项目(2013243)
关键词
固本养脏汤
慢性阻塞性肺疾病
急性加重期
肺动脉高压
机制
Guben Yangzang Tang
Chronic obstructive pulmonary disease
Acute exacerbation period
Pulmonary arterial hypertension
Mechanism
