摘要
作者用诱发小鼠肺肿瘤短期试验证明氯丁二烯的致癌性。结果表明:吸入氯丁二烯2.9、19.2和189mg/m^3后,均可使小鼠肺肿瘤发生率增高;出现肺肿瘤多发性增加,并呈现良好的剂量反应关系。由于本研究所用最高浓度189mg/m^3在生产现场并非偶尔出现,故本研究结果提示了氯丁二烯的致癌性,并进一步支持本室关于氯丁二烯作业人员肿瘤流行病学调查的结果。
In a previous report by the authors,positive results in both case-control studymouse lung tumor induction short-term testof chloroprene for carcinogenicity was con-ducted to determine whether chloroprenemonomer itself could induce tumor.Kuang-ming albino mice weaned 2 wk weresubjected to inhale 0.0, 2.9±0.34, 19.18±1.89, 189.00±13.26mg/m^3, chloroprene (GCpurity 99.69%) 4 h daily (except Sunday)for 7 month. All survivors were killed atthe end of the 8th month or when mori-bund. No lung tumor was found before the6th month.Thus survivors at the 6th monthwere counted as effective animals. Mostlung tumors observed were papillo-adenoma(50/57); and a few were adenoma (7/57).Tumor incidence of the 2.9mg/m^3 group in-creased to 8.1% in comparison with that ofthe control group (1.3%) at a significantlevel of P<0.05; and the higher the concen-tration the higher the incidence. Examina-tion of the multiplicity of tumors also de-monstrated the dose-response relationship,and the number of tumors per mouse inthe 189mg/m^3 group was significant atP<0.01.
出处
《华西医科大学学报》
CAS
CSCD
1989年第3期299-302,共4页
Journal of West China University of Medical Sciences
