摘要
目的:检测膜型-1基质金属蛋白酶(MMP-14)在卵巢透明细胞癌和卵巢浆液性肿瘤中的表达并探讨其临床意义。方法:采用免疫组化的方法检测35例卵巢透明细胞癌、39例卵巢浆液性癌、22例卵巢交界性浆液性肿瘤和24例卵巢浆液性囊腺瘤标本中MMP-14蛋白的表达,探讨其与卵巢透明细胞癌和浆液性肿瘤临床病理因素的关系。结果:MMP-14阳性染色定位于肿瘤细胞;其中透明细胞癌阳性率为94.3%,浆液性癌阳性率为43.5%,二者相比差异显著(P<0.01)。交界性浆液性肿瘤阳性率为45.5%,浆液性囊腺瘤阳性率为8.3%,和浆液性癌相比,差异显著(P<0.01)。MMP-14蛋白的表达与透明细胞癌、浆液性癌的临床分期、淋巴结转移和Ki-67的表达无相关性(P>0.05)。结论:卵巢透明细胞癌中MMP-14蛋白的高表达反应肿瘤有更高的恶性生物学行为并有可能成为卵巢透明细胞癌不良预后的一个指标。
Objective：To investigate the expression and clinical significance of MMP - 14 protein in clear cell carcinomas of the ovary. Methods ： Thirty - five clear cell carcinomas of the ovary and eighty - five serous tumor of the ovary tissues were collected. MT1 - MMP protein was detected by immunohistochemistry assay and their correlations with clinicopathological factors were analyzed. Results：The expression of MMP - 14 protein was positive in 94.3% of clear cell carcinomas of the ovary ,which was higher than that in serous carcinoma 43.5% （P 〈0.01 ）. The positive rates were 43.5% ,45.5% and 8.3% in serous carcinoma, borderline serous tumor and serous cystadenoma of the ovary respectively（ P 〈 0.01 ）. MMP - 14 protein showed no relation with clinical stage ,lymphoid node metastasis or Ki - 67 （P 〉 0.05）. Conclusion ： MMP - 14 protein in clear cell carcinomas of the ovary was higher expression. It can be a predictor for the ability of clear cell carcinomas of the ovary invasion and metatasis.
出处
《现代肿瘤医学》
CAS
2016年第3期448-451,共4页
Journal of Modern Oncology
基金
无锡市卫生局面上项目(编号:MD201308)
