摘要
目的:比较艾灸关元、肾俞、足三里与西药对脑瘫患儿免疫功能的影响。方法:230例脑瘫患儿随机分为观察组和对照组,每组115例。观察组于关元、肾俞、足三里穴行温和灸;对照组口服匹多莫德口服液,每次10 mL。两组均每日1次,30天为一疗程,共治疗90天。分别于治疗30天、60天、90天比较两组T淋巴细胞亚群、血清免疫球蛋白及发育商的变化,并于治疗后6、12个月随访患儿疾病发生率。结果:两组治疗30、60、90天后均较治疗前明显提高T淋巴细胞亚群(CD_3^+、CD_4^+、CD_4^+/CD_8^+)、血清免疫球蛋白(IgG、IgA)及发育商(P<0.01,P<0.05);在CD_3^+、CD_4^+、CD_4^+、CD_8^+及IgG、IgA、发育商方面,治疗30天后对照组优于观察组(均P<0.05),治疗60天后两组差异无统计学意义(均P>0.05),治疗90天后观察组优于对照组(均P<0.05);CD_8^+、IgM两组治疗前后比较差异无统计学意义(均P>0.05)。观察组不良反应发生率为7.0%(8/115)低于对照组的23.5%(27/115,P<0.01);观察组治疗后6、12个月随访患儿疾病发生率明显低于对照组(P<0.05)。结论:艾灸关元、肾俞、足三里可改善脑瘫患儿的免疫功能,疗效优于西药匹多莫德。
Objective To compare the effects between moxibustion at Guanyuan（CV 4）,Shenshu（BL 23）,Zusanli（ST 36） and western medication on immune function in children with cerebral palsy.Methods A total of230 children with cerebral palsy were randomly divided into an observation group and a control group,115 cases in each one.Patients in the observation group were treated with warm moxibustion at Guanyuan（CV 4）,Shenshu（BL 23） and Zusanli（ST 36）.Patients in the control group were treated with oral administration of pidotimod 10 mL every time.The treatment was given once a day,and 30 days were considered as one session for total 90 days.The changes of T-lymphoctyte subgroups,serum immunoglobulin and development quotient were compared 30 days,60 days and 90 days into treatment respectively;also the occurrence rate of disease was observed during 6-month and 12-month follow-up visit.Results The T-lymphoctyte subgroups（CD3＋,CD4＋,CD4＋/CD8＋）,serum immunoglobulin（IgG,IgA） and development quotient were significantly improved 30 days,60 days and90 days into treatment（P〈0.01,P〈0.05）.Regarding the changes of CD3＋,CD4＋,CD4＋ /CD8＋,IgG,IgA and development quotient,the control group was superior to the observation group 30 days into treatment（all P〈0.05）,and the control group was similar to the observation group 60 days into treatment（all P〉0.05）,and the observation group was superior to the control group 90 days into treatment（all P〈0.05）.There was no significant difference of CD8＋ and IgM before and after treatment in two groups（all P〉0.05）.The rate of adverse events was7.0%（8/115） in the observation group,which was lower than 23.5%（27/115） in the control group（P〈0.01）;during 6-month and 12-month follow-up visit,the occurrence rate of disease in the observation group was lower than that in the control group（P〈0.05）.Conclusion Moxibustion at Guanyuan（CV 4）,Shenshu（BL 23） and Zusanli（ST 36） can improve immune function of children with cerebral palsy,which is superior to pidotimod.
出处
《中国针灸》
CAS
CSCD
北大核心
2016年第1期12-16,共5页
Chinese Acupuncture & Moxibustion
关键词
脑性瘫痪
艾灸
关元
肾俞
足三里
药
匹多莫德口服液
免疫功能
随机对照研究
cerebral palsy
moxibustion
Point CV 4（Guanyuan）
Point BL 23（Shenshu）
Point ST 36（Zusanli）
drug,pidotimod
immune function
randomized controlled trial（RCT）
