摘要
目的探讨CT联合血清糖链抗原19-9（CA19-9）、癌胚抗原（CEA）、糖链抗原125（CA125）对胰腺癌的诊断价值。方法人选68例胰腺占位性病变患者，根据病理诊断结果分为胰腺癌组（n=43）和非胰腺癌组（n=25），另收集健康体检者34例作为对照组。所有患者均行CT检查并将cT诊断结果与病理结果进行一致性分析，化学发光法检测所有入选者血清CA19-9、CEA、CA125，分析CT联合血清CA19-9、CEA、CA125诊断胰腺癌的敏感度、特异度和准确度。结果68例患者中CT诊断为胰腺癌35例，CT诊断结果与病理结果一致性不够理想；非参数检验发现胰腺癌组血清CAl9-9、CEA、CAl25均高于非胰腺癌组和对照组，差异有统计学意义（P〈0．05），而非胰腺癌组和对照组比较差异无统计学意义（P〉0．05）。结论CT诊断胰腺癌的敏感度高但特异度低，CT联合血清CA19-9、CEA、CA125可在不降低敏感度的前提下，提高特异度，从而提高胰腺癌诊断准确度，具有较高的临床实用价值。
Objective To study the diagnostic value of CT combined with serum carbohydrate antigenlg- 9（CA19-9）, carcinoembryonic antigen （CEA）, carbohydrate antigen 125 （CA125）in diagnosis of pancreatic cancer. Methods 68 patients with pancreatic occupying lesions were selected and they were divided into pancre- atic cancer group（ n= 43 ） and non-pancreatic cancer group（ n = 25 ） according to pathological diagnosis. 34 cases from physical examination were set as the control group. All patients received CT examination and the consistency between CT diagnosis and pathological results was analyzed. Serum CA19-9, CEA, and CA125 were detected by chemiluminescence method. The sensitivity, specificity and accuracy of CT combined serum CA19-9, GEA, CA125 were analyzed. Results Among the 68 cases, 35 cases were pancreatic cancer diagnosed by CT, and the CT diagnosis was not ideal compared with pathological results. Nonparametric test found that serum CA19-9, CEA and CA125 in pancreatic cancer group were higher than those of the non-pancreatic cancer group and the control group, and the difference had statistical significance （P 〈 0. 05）, while the difference between non-pancreatic cancer group and the control group had no statistical significance （ P 〉 0.05 ）. Conclusion CT diagnosis had high susceptibility and low specificity,CT combined with serum CA19-9 ,CEA, and CA125 can improve accuracy of pancreatic cancer diagnosis.
出处
《中华内分泌外科杂志》
CAS
2015年第6期476-479,共4页
Chinese Journal of Endocrine Surgery
关键词
CT
糖链抗原19-9
癌胚抗原
糖链抗原125
胰腺癌
Computed tomography（CT）
Carbohydrate antigen19-9
Carcinoembryonic antigen
Carbohydrate antigen 125
Pancreatic cancer
