摘要
目的比较不同发育速度囊胚冻融后移植的妊娠结局及新生儿状况。方法回顾性分析2012年1月-2014年1月在沈阳东方医疗集团菁华医院生殖中心进行冻融囊胚移植的3285个周期,按照囊胚发育速度及移植枚数分为四组:D5单囊胚组778例,D6单囊胚组808例,D5双囊胚组651例,D6双囊胚组1048例。分别比较D5与D6单囊胚组、D5与D6双囊胚组临床妊娠率、种植率、流产率、异位妊娠率、多胎率、早产率、低出生体重(LBW)率、新生儿男女比例、出生缺陷等指标。结果D5单囊胚组临床妊娠率及种植率显著高于D6单囊胚组(P<0.05);流产率、异位妊娠率、多胎率、早产率、LBW率、新生儿男女比例和出生缺陷两组间比较,差异无统计学意义(P>0.05)。D5双囊胚组临床妊娠率、种植率、多胎妊娠率显著高于D6双囊胚组(P<0.05);其它指标两组间无显著差异。结论复苏周期移植D5囊胚比D6囊胚可以获得更好的妊娠结局,不同发育速度囊胚的出生结局及新生儿状况无显著差异。
Objective：To compare the birth outcomes and neonatal status of frozen thawed blastocysts with different development speed. Methods：3285 cycles of thawed blastocysts transferred were retrospectively analyzed.They were divided into four groups according to the day of blastocyst development and the number of embryo transferred：single blastocyst transferred on Day5（n=778）,single blastocyst transferred on Day6（n=808）,double blastocysts transferred on Day5（n=651）,double blastocysts transferred on Day6（n=1048）.We compared clinical pregnancy rate,implantation rate,abortion rate,ectopic pregnancy rate,multiple pregnancy rate,premature delivery rate,low birth weight rate,newborn sex,birth defects and so on. Results：Compared with Day6 single blastocyst group,there was higher clinical pregnancy rate and implantation rate in Day5 single blastocyst group（P〈0.05）. No significant differences were detected in miscarriage rate,ectopic pregnancy rate,multiple pregnancy rate,premature delivery rate,low birth weight rate,newborn sex,birth defects between the Day5 and Day6 single blastocyst groups.Compared with Day6 double blastocysts group,there were higher clinical pregnancy rate,implantation rate and multiple pregnancy rate in Day5 double blastocysts group（P〈0.05）,but no significant difference were found in other index. Conclusion：The pregnancy outcomes in frozen embryo transfer of D5 were better than D6.No significant difference were detected in birth outcomes and neonatal status of blastocysts with different development speed.
出处
《中国优生与遗传杂志》
2015年第12期103-105,108,共4页
Chinese Journal of Birth Health & Heredity
关键词
冻融囊胚移植
妊娠结局
出生结局
Frozen-thawed blastocyst transfer
Pregnancy outcome
Birth outcome
