摘要
目的探讨毛细支气管炎患儿血清25-(OH)-D3水平、尿LTE4水平变化的临床意义及维生素D3干预对尿LTE4的影响。方法选择毛细支气管炎急性期患儿76例作为毛细支气管炎组,另选取同期在我院儿童保健门诊体检的60例健康儿童作为对照组。毛细支气管炎组患儿给予常规治疗,进入恢复期后,随机分为维生素D3干预组和未干预组,每组各38例,干预组予维生素D3滴剂400IU/天口服,未干预组不予处理,随访6个月。分别于入院次日(急性期)、维生素D3干预前一日(恢复期)检测各组患儿血清25-(OH)-D3和尿LTE4水平,并干预6个月后检测干预组及未干预组尿LTE4水平。结果毛细支气管炎重型及轻型患儿血清25-(OH)-D3水平均明显低于对照组;而尿LTE4则明显高于对照组;重型患儿血清25-(OH)-D3水平明显低于轻型患儿,尿LTE4水平明显高于轻型(P<0.05);急性期及恢复期血清25-(OH)-D3水平均低于对照组,尿LTE4水平明显高于对照组;急性期25-(OH)-D3水平明显低于恢复期;尿LTE4水平则明显高于恢复期(P均<0.01)。血清25-(OH)-D3与毛细支气管炎病情轻重呈负相关(r=-0.68,P<0.01),尿LTE4与病情轻重呈正相关(r=0.76,P<0.01);血清25-(OH)-D3与尿LTE4呈负相关(r=-0.63,P<0.05)。干预后,干预组及未干预组尿LTE4水平比较,两组之间差异无统计学意义(P>0.05)。结论毛细支气管炎患儿急性期维生素D3干预对尿LTE4无下调作用。
Objective To study the clinical value of serum 25-（ OH）-D3 and urine LTE4 levels in children with bronchiolitis and intervention of vitamin D3 for urine leukotriene E4 level. Methods 76 infants with bronchiolitis were selected as the bronchiolitis group,and 60 healthy children were taken as the control group. All the children with bronchiolitis were given conventional treatment,and then they were randomly divided into the vitamin D3 intervention group（ 400 IU per day） and the non-intervention control group after symptom remission. They were followedup for 6 months. The serum levels of 25-（ OH）-D3 and urine LTE4 were detected at the acute phase and recovery phases between the two groups. Results Compared with the healthy children,the level of serum 25-（ OH）-D3 was significantly lower in children with severe and mild bronchiolits,and the level of urine LTE4 were significantly higher.The level of serum 25-（ OH）-D3 in the severe group was lower than that in the mild group,and the level of urine LTE4 was higher in the severe group than that in the mild group（ P 〈0. 05）. Compared with the control group,the level of serum 25-（ OH）-D3 was lower at acute phase and recovery phase. The level of urine LTE4 was obviously higher in the bronchiolitis group than in the control group. Compared with the recovery group,the level of serum 25-（ OH）-D3 was lower and urine LTE4 was higher at acute phase. The Spearman relevant analysis showed there was a negative correlation between 25-（ OH）-D3 and the severity of disease and a positive correlation between urine LTE4 and the severity of disease. The linear correlation analysis showed that there was a negative correlation between 25-（ OH）-D3 and LTE4. After vitamin D3 intervention,there was no statistical difference in the level of urine LTE4 between the intervention group and the non-intervention group（ P 〉0. 05）. Conclusion The Vitamin D3 intervention can not decrease the level of urine LTE4 in children with bronchiolitis.
出处
《临床肺科杂志》
2016年第1期91-94,共4页
Journal of Clinical Pulmonary Medicine
