摘要
目的：分析重组人脑利钠肽辅助介入治疗对急性心肌梗死合并心源性休克患者预后情况的影响。方法：选取2013年3月～2015年3月陕西省宝鸡市中心医院心内科收治的住院患者112例，均为发病12h内的急性心肌梗死且接受直接PCI治疗的患者。按照随机数表法将入组患者分为观察组及对照组各56例，对照组患者接受常规介入治疗，观察组患者接受重组人脑利钠肽辅助介入治疗，对比两组患者的治疗后局部心肌形变能力、心肌酶谱指标、脑利钠肽及炎症因子、血糖及应激激素、心肌梗死预后相关指标等差异。结果：观察组患者的治疗后LVEF、SRs、SRe、Sra水平高于对照组，WMSI水平低于对照组患者（均P〈0．05）；血清CK、CK-MB、AST、LDH等心肌酶谱指标值低于对照组患者（P〈0．05）；血清BNP、CRP、TNF-α、IL-6水平低于对照组患者（P〈0．05）；血清皮质醇、生长激素及胰高血糖素水平低于对照组，胰岛素水平高于对照组患者（均P〈0．05）；FT3、IGF-1水平高于对照组，sPLA2、Hcy值低于对照组患者（均P〈0．05）。结论：急性心肌梗死合并心源性休克患者接受重组人脑利钠肽辅助介入治疗，可以减少心肌功能损伤并保护心肌正常功能、优化患者远期预后，具有积极的临床意义。
Objective： To analyze the effect of recombinant human brain natriuretic peptide-- assisted interventional treatment on prognosis of acute myocardial infarction patients complicated with cardiogenic shock. Methods： A total of 112 ad- mitted in our hospital from March 2013 to March 2015 were selected, who had acute myocardial infarction within 12 h of onset and received direct PCI treatment. They were divided into observation group and control group according to random number ta-ble, each group with 56 cases. Patients in control group received conventional interventional treatment and observation group received recombinant human brain natriuretic peptide-assisted interventional treatment. Then differences of regional myocar- dial deformability, myocardial enzyme spectrum indicators, brain natriuretic peptide and inflammatory factors, blood sugar and stress hormones as well as myocardial infarction prognosis-associated indexes, etc, between two groups after treatment were compared. Results： After treatment, LVEF, SRs, SRe and Sra levels of observation group were significantly higher than those of control group, WMSI level was significantly lower than that of control group （P〈0.05）. Serum myocardial enzyme spec- trum indicators CK, CK-MB, AST and LDH values were significantly lower than those of control group （P〈0.05）. Serum BNP, CRP, TNF-α and IL-6 levels were significantly lower than those of control group （P〈0.05）. Serum cortisol, growth hormone and glucagon levels were significantly lower than those of control group, insulin level was significantly higher than that of control group （P〈0.05）. FT3 and IGF-1 levels were significantly higher than those of control group, sPLA2 and Hey levels were significantly lower than those of control group （P〈0.05）. Conclusion： Recombinant human brain natriuretic pep- tide- assisted interventional treatment can reduce myocardial function injury, protect normal myocardial function and optimize patients’ long--term prognosis of acute myocardial infarction patients complicated with cardiogenic shock.
出处
《海南医学院学报》
CAS
2016年第2期133-137,共5页
Journal of Hainan Medical University
基金
广州中医药大学第一临床医学院2015年学院教育教学课题-<内科学>双语案例教学精品课程建设(20151514)~~
关键词
急性心肌梗死
心源性休克
重组人脑利钠肽
介入治疗
Acute myocardial infarction
Cardiogenie shock
Recombinant human brain natriuretic peptide
Interven- tional treatment
