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麻醉药物联合低温治疗难治性癫癎持续状态

Combined use of intravenous anesthetics and hypothermia in treating refractory status epilepticus
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摘要 静脉注射麻醉药物虽为治疗难治性癫癎持续状态的首选方法,但仍有部分患者不能有效控制发作,只能选择联合其他治疗方法。低温治疗不仅可以终止癫癎发作,尚具有一定脑保护作用。麻醉药物联合低温治疗终止癫癎持续状态的良好效果已被大量临床研究证实,本文拟对其麻醉药物剂量、低温施用时机、温度、具体方法,以及联合治疗适应证和禁忌证等进行概述,以使更多临床医师了解此项治疗措施的机制和应用方法。 The primary choice of treating refractory status epilepticus(RSE) is intravenous anesthetics, but the seizures of some patients can not get a good control. Thus, other therapies must be combined. Hypothermia not only can terminate seizures, but also play a part in brain protection. Though combined use of intravenous anesthetics and hypothermia is not a regular clinical scheme, the favorable effect has been proved by a lot of clinical research. This paper mainly focuses on the dose of intravenous anesthetics, the time, temperature and procedure of hypothermia, the indications and contraindications of combined therapy, and so on.
出处 《中国现代神经疾病杂志》 CAS 2015年第11期866-869,共4页 Chinese Journal of Contemporary Neurology and Neurosurgery
基金 国家临床重点专科建设项目-神经内科 国家临床重点专科建设项目-重症医学科 国家高技术研究发展计划(863计划)项目(项目编号:2015AA020514)~~
关键词 癫癎持续状态 重症监护病房 麻醉药 低温 综述 Status epilepticus Intensive care units Anesthetics Hypothermia Review
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  • 1Theodore WH,Porter RJ,Albert P,et al.The secondarily generalized tonic-clonic seizure:a videotape analysis.Neurology,1994,44:1403-1407.
  • 2Shinnar S.Who is at risk for prolonged seizures? J Child Neurol,2007,22 (5 Suppl):14-20.
  • 3Chin RF,Neville BG,Peckham C,et al.Treatment of communityonset,childhood convulsive status epilepticus:a prospective,population-based study.Lancet Neurol,2008,7:696-703.
  • 4Chen JW,Wasterlain CG.Status epileptieus:pathophysiology and management in adults.Lancet Neurol,2006,5:246-256.
  • 5Afra P,Jouny CC,Bergey GK.Duration of complex partial seizures:an intracranial EEG study.Epilepsia,2008,49:677-684.
  • 6Lowenstein DH,Bhck T,Macdonald RL.It's time to revise the definition of status epilepticus.Epilepsia,1999,40:120-122.
  • 7Wasterlain CG,Chen JW.Mechanistic and pharmacologic aspects of status epilepticus and its treatment with new antiepileptic drugs.Epilepsia,2008,49 Suppl 9:63-73.
  • 8Goodkin HP,Joshi S,Mtchedlishvili Z,et al.Subunit-specific trafficking of GABA (A) receptors during status epilepticus.J Neurosci,2008,28:2527-2538.
  • 9Deshpande LS,Lou JK,Mian A,et al.Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus:role of NMDA receptor activation and NMDA dependent calcium entry.Eur J Pharmacol,2008,583:73-83.
  • 10Goodkin HP,Liu X,Holmes GL.Diazepam terminates brief but not prolonged seizures in young,naive rats.Epilepsia,2003,44:1109-1112.

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