摘要
【目的】探讨孕妇乙型肝炎病毒（HBV ）感染对新生儿感染的影响。【方法】选取本院产科门诊及住院孕产妇进行乙肝两对半筛查，HBsAg阳性者106例按乙肝两对半检测结果分为HBsAg、HBeAg、HBcAb阳性组26例（A组），HBsAg、HBeAb、HBcAb阳性组74例（B组）和HBsAg、HBcAb阳性组6例（C组），抽取分娩前孕妇静脉血和新生儿分娩时采取脐血检测乙肝五项和 HBV‐DNA定量，分析 HBV‐DNA定量与新生儿宫内感染的相关性。【结果】106例HBsAg阳性孕妇，10例新生儿 HBsAg阳性，占94．3％。A、B、C组新生儿宫内感染率分别为130．4％（3／26）、81．1％（6／74）、166．7％（1／6），三组新生儿宫内感染率比较无显著性差异（F＝12．04，P ＝01．63）。不同HBV‐DNA 载量组新生儿宫内感染率比较有显著性差异（F＝52．04，P ＜00．5），HBV‐DNA载量与新生儿宫内感染呈正相关（ r ＝06．72，P ＝00．15）。【结论】HBV血清标志物不能完全反应HBV宫内感染情况，及时检测孕妇血清中HBV‐DNA载量，积极采取相应措施，有助于预防新生儿宫内感染。
Objective]To investigate the effect of hepatitis B virus intrauterine infection on neonatal in‐fants .[Methods]One hundred and six cases of pregnant women with HBsAg positive results in our hospital from Jan .2010 to Dec .2014 were used as an observation group .According to HBV Casset results ,106 cases of pregnant women were divided into a HBsAg ,HBeAg ,and HBcAb positive group （26 cases） ,a HBsAg , HBeAb ,and HBcAb positive group （74 cases） and a HBsAg ,HBcAb positive group （6 cases） .Venous blood of pregnant women and cord blood of infants were collected to determine HBV 5 tests and HBV DNA quantifi‐cation test .[Results]Ten infants were found to be HBsAg positive among 106 cases of pregnant women with HBsAg positive results ,accounting for 9 4.3% of the patients .There were no significant differences among the intrauterine infection rates of the 3 groups （F=1 .204 ,P =0 1.63） .However ,there were significant differ‐ences among the groups＆#39;HBV DNA capacities （F=5 2.04 ,P 〈0 0.5） .Furthermore ,HBV DNA copy and in‐trauterine infection was positively corelated （ r =0 6.72 ,P =0 0.15） .[Conclusion]Using HBV serum land‐marks for intrauterine infection detecting is not suitable .Thus ,detecting the serum HBV DNA copy of preg‐nant women will help decrease the risk of intrauterine infection .
出处
《医学临床研究》
CAS
2015年第11期2095-2097,共3页
Journal of Clinical Research
