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骨肉瘤相关微小RNA的研究进展 被引量：3

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摘要 骨肉瘤（osteosarcoma）是最常见的原发性恶性骨肿瘤。随着新辅助化疗方案研究的不断改善,以及影像学发展带来的肿瘤边界判定和病情检测水平的提高,新辅助化疗联合手术治疗的综合治疗策略使得骨肉瘤患者的5年生存率有所提高。但是化疗抵抗和肺转移仍是骨肉瘤不良预后的重要原因和难以逾越的屏障。
作者 朱天波 田青松 胡兆华 单喆 李新志
机构地区 三峡大学仁和医院骨外科
出处 《广东医学》 CAS 北大核心 2015年第21期3409-3411,共3页 Guangdong Medical Journal
基金 三峡大学研究生科研创新基金资助项目(编号:2015CX097)
关键词 骨肉瘤细胞 新辅助化疗 影像学发展 OSTEOSARCOMA 肺转移 骨肉瘤组织 肿瘤边界 骨肉瘤诊断 检测水平 RNA
分类号 R738.1 [医药卫生—肿瘤]
  • 相关文献

参考文献24

  • 1ARABI L, GSPONER J R, SMIDA J, et al. Upregulation of the miR- 17 -92 cluster and its two paraloga in osteosarcoma -rea- sons and consequences[J]. Genes Cancer, 2014, 5(1/2) : 56 - 63.
  • 2MIAO J, WU S, PENG Z, et al. MicroRNAs in osteosarcoma : di- agnostic and therapeutic aspects [ J ]. Tumour Biol, 2013, 34 (4) : 2093 - 2098.
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  • 4ZHOU G, SHI X, ZHANG J, et al. MicroRNAs in osteosarcoma: from biological players to clinical contributors, a review[ J]. J Int Med Res, 2013, 41(1) : 1 -12.
  • 5赵亚恒,冯和林,郑丽华,贾志峰,冯建刚.骨肉瘤发病机制的研究进展[J].肿瘤防治研究,2014,41(3):283-286. 被引量：25
  • 6HU H, ZHANG Y, CAI X H, et al. Changes in microRNA ex- pression in the MG - 63 osteosarcoma cell line compared with oste- oblasts[J]. Oncol Lett, 2012, 4(5) : 1037 - 1042.
  • 7WON K Y, KIM Y W, KIM H S, et al. MicmRNA - 199b -5p is involved in the Notch signaling pathway in osteosarcoma[ J]. Hum Pathol, 2013, 44(8): 1648-1655.
  • 8LULLA R R, COSTA F F, BISCHOF J M, et al. Identification of differentially expressed micmRNAs in osteosarcoma [ J ]. Sarcoma, 2011,2011 : 732690.
  • 9DI FIORE R, FANALE D, DRAGO FERRANTE R, et al. Genetic and molecular characterization of the human osteosareoma 3AB - OScancer stem cell line: a possible model for studying osteosarcoma origin and stemness[J]. J Cell Physiol, 2013, 228(6): !189,- 1201.
  • 10FEI D, LI Y, ZHAO D, et al. Serum miR - 9 as a prognostic bio- marker in patients with osteosarcoma[J].J Int Med Res, 20141 42(4) :932 -937.

二级参考文献12

  • 1W. Zhang,J. Qian,H. Yi,Z. Yang,C. Wang,J. Chen,X. Wei,Q. Fu,H. Ma.The microRNA-29 plays a central role in osteosarcoma pathogenesis and progression[J]. Molecular Biology . 2012 (4)
  • 2Matthew L. Broadhead,Jonathan C. M. Clark,Damian E. Myers,Crispin R. Dass,Peter F. M. Choong,H. Kovar.The Molecular Pathogenesis of Osteosarcoma: A Review[J]. Sarcoma . 2011
  • 3J. W. Martin,M. Zielenska,G. S. Stein,A. J. van Wijnen,J. A. Squire,Stephen Lessnick.The Role of RUNX2 in Osteosarcoma Oncogenesis[J]. Sarcoma . 2010
  • 4Yin-He Wang,Jin Xiong,Shou-Feng Wang,Yang Yu,Bin Wang,Yi-Xin Chen,Hong-Fei Shi,Yong Qiu.Lentivirus-mediated shRNA targeting insulin-like growth factor-1 receptor (IGF-1R) enhances chemosensitivity of osteosarcoma cells in vitro and in vivo[J]. Molecular and Cellular Biochemistry . 2010 (1-2)
  • 5AikateriniBerdiaki,Georgios A.Datsis,DraganaNikitovic,AristidisTsatsakis,PavlosKatonis,Nikos K.Karamanos,George N.Tzanakakis.Parathyroid hormone (PTH) peptides through the regulation of hyaluronan metabolism affect osteosarcoma cell migration[J]. IUBMB Life . 2010 (5)
  • 6Virna D. Leaner,Jeffrey F. Chick,Howard Donninger,Ilona Linniola,Arnulfo Mendoza,Chand Khanna,Michael J. Birrer.Inhibition of AP-1 Transcriptional Activity Blocks the Migration, Invasion, and Experimental Metastasis of Murine Osteosarcoma[J]. The American Journal of Pathology . 2009 (1)
  • 7Hang T. Ta,Crispin R. Dass,Peter F. M. Choong,Dave E. Dunstan.Osteosarcoma treatment: state of the art[J]. Cancer and Metastasis Reviews . 2009 (1-2)
  • 8Joshua T. Mendell.miRiad Roles for the miR-17-92 Cluster in Development and Disease[J]. Cell . 2008 (2)
  • 9Hye-Rim Park,Woon Won Jung,Franco Bertoni,Patrizia Bacchini,Jae Hoon Park,Youn-Wha Kim,Yong-Koo Park.Molecular analysis of p53, MDM2 and H-ras genes in low-grade central osteosarcoma[J]. Pathology - Research and Practice . 2004 (6)
  • 10Simon J.Cotterill,Charlotte M.Wright,Mark S.Pearce,Alan W.Craft.Stature of young people with malignant bone tumors[J]. Pediatr. Blood Cancer . 2003 (1)

共引文献24

同被引文献25

引证文献3

二级引证文献11

广东医学
2015年 第21期

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