摘要
目的评估流行性乙型脑炎（乙脑）减毒活疫苗（Japanese Encephalitis Attenuated Live Vaccine,JEV-L）大规模预防接种对乙脑发病趋势的影响。方法收集贵州省1990-2014年乙脑发病率,利用中断时间序列分析方法和分段回归模型进行定量分析乙脑发病率变化趋势。结果 JEV-L大规模预防接种后,乙脑发病率立即下降（β2=-1.4541,P=0.035）;并产生了长期作用,乙脑发病率逐年下降（β3=-0.3193,P=0.003）。结论在乙脑发病率较高的地区,开展一次JEV-L大规模预防接种,继而将其纳入免疫规划,可显著降低乙脑发病水平。
Objective To assess the impact of Japanese encephalitis（ JE） attenuated live vaccine（ JEV-L）administrationon the trend of JE incidence. Methods We collected JE incidence rates from 1990 through2014 in Guizhou province and analyzed trends using interrupted time series and segmented regression models.Results After the JEV-L catch-up campaign,the JE incidence decreased immediately（ β2=- 1. 4541,P =0. 035） and continued to decrease every year（ β3=- 0. 3193,P = 0. 003）. Conclusions In endemic JE settings,an effective immunization strategy is a one-time JEV-L catch-up campaign followed by introduction of JEV-L into the routine immunization program.
出处
《中国疫苗和免疫》
北大核心
2015年第4期361-364,共4页
Chinese Journal of Vaccines and Immunization
关键词
中断时间序列
流行性乙型脑炎减毒活疫苗
有效性
Interrupted time series
Japanese encephalitis attenuated live vaccine
Effectiveness
