摘要
目的探讨依达拉奉联合法舒地尔治疗急性脑梗死的临床效果和安全性。方法选取我院2013年2月至2015年2月收治住院的急性脑梗死患者118例,随机分为观察组和对照组各59例。对照组给予盐酸法舒地尔治疗,观察组在对照组的基础上加用依达拉奉治疗。两组患者疗程均为2周。评价以下指标:(1)分别于治疗前后测定两组患者血浆NO及ET-1水平;(2)依据脑卒中神经功能缺损程度(NDS)评分标准,对两组患者治疗前后神经功能缺损程度进行评价;(3)统计比较两组治疗有效率;(4)统计分析两组不良反应的发生率。结果治疗后,观察组NO及ET-1水平改善情况优于对照组,NDS评分改善情况优于对照组,治疗有效率高于对照组,差异均有统计学意义(P<0.05)。两组治疗中均未见出血、过敏等不良反应,患者耐受性良好。结论依达拉奉联合法舒地尔治疗急性脑梗死,可改善患者的脑血管内功能,改善患者的神经功能,提高临床治疗效果,具有较高的安全性,值得临床推广应用。
Objective To investigate the effic acute cerebral infarction. Methods A total acy of our hospital from February 2013 to February and safety of edaravone combined with fasudil on 118 acute cerebral infarction patients chosen from 2015 were divided into observation group and con trol group, with 59 cases in each group. The control group was treated with fasudil hydrochloride treatment, the observation group was treatment were both two weeks. And gl th ven edaravone based on the control group. The course of e following indicators were analyzed ： （1） Before treatment and after treatment, the plasma NO and ET-1 levels in two groups of patients. （2）Based on the neurologic impairment of cerebral stroke （NDS） score standar two groups were compared. （3）The treatment efficiency rate. d, the neurologic impairment in the （4）The incidence of adverse reactions. Results After treatment, the levels of NO and ET-1 in the observation than those in the control group（P〈0.05）. The NDS scores in the observation group group were were better better than those in the control group（P〈0.05）. The effective rate of the observation group was higher than that of the control group（P〈0.05）. No adverse reactions, such as bleeding and allergic re action were found in the two groups, and all were well tolerated. Conclusion Edaravone corn bined with fasudil in the treatment of acute cerebral infarction can improve the function in the patients with cerebral vascular, improve neurological function and the clinical treatment effect, which is security and worthy of clinical application.
出处
《青岛医药卫生》
2015年第6期407-410,共4页
Qingdao Medical Journal
