摘要
目的：评价治疗前外周血中性粒细胞与淋巴细胞比值（neutrophil-to-lymphocyte ratio,NLR）在宫颈癌放疗患者中的预测意义。方法：回顾性分析230例Ⅰ~Ⅳ期单纯放疗或同步放化疗宫颈癌患者的病例资料,通过建立受试者工作特征曲线（ROC曲线）,确定治疗前NLR预测放疗疗效的最佳临界值,并按最佳临界值分为NLR低组、NLR高组,分析两组与放疗疗效的关系,并比较总体生存时间、无病进展生存时间。结果：治疗前NLR预测疗效的最佳临界值为2.84,单因素分析显示NLR与放疗疗效相关（P〈0.001）,Cox多因素分析结果显示NLR高值为影响总生存时间的独立危险因素,NLR高组1、3年总生存率比NLR低组短（65.5%vs.86.2%,32.4%vs.62.5%;P〈0.001）。结论 ：治疗前NLR可作为预测宫颈癌放疗或同步放化疗疗效的一项重要指标,具有易测定、重复好、价格低廉的优点,值得临床推广应用。
Objective To evaluate the predictive value of NLR in response to radiation therapy alone or concurrent chemoradiation therapy and the prognostic outcome. Methods Pretreatment NLR was evaluated in 230 paitents, with clinically staged cervical cancer （ Ⅰ-Ⅳ ）, received RT or CCRT therapy, Receiver operating characteristic curves were applied to establish optimal cutoff points, and all 230 patients were therefore divided into two groups based on the NLR value, and univariate and multivariate analyses were used to estimate radiation response, Kaplan-Meier method was used to estimate the OS and DFS. Results ROC curve analysis demonstrated the best cut-of values for NLR （ ≥ 2.84）for radiation response. Results of Cox regression showed that NLR was significantly associated with the overall survival （OS）. The high NLR group was poor in 1-year OS and 3-year OS compared with those in the low NLR group （65.5% vs 86.2%,32.4% vs 62.5%;P 〈 0.001）. Conclusions Pre- treatment blood NLR could predict a good response to RT or CCRT, and could be a useful biomarker for cervical cancer patients before RT or CCRT, with the merits including easy measurement, reproducible and unexpensive marker of systemic inflammation.
出处
《实用医学杂志》
CAS
北大核心
2015年第22期3697-3700,共4页
The Journal of Practical Medicine
基金
自治区科技支疆项目基金资助(编号:201591152)
关键词
宫颈肿瘤
中性粒细胞与淋巴细胞比值
放疗
同步放化疗
预后
Uterine cervical neoplasms
Neutrophil-lymphocyte ratio
Radiation therapy
Concurrent ehemoradiation, Prognosis
