可溶性髓系细胞触发受体-1在婴幼儿社区获得性肺炎中的作用被引量：5

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摘要目的研究可溶性髓系细胞触发受体-1（sTREM-1）在婴幼儿社区获得性肺炎中的作用。方法选择无锡市儿童医院2010年1月至2013年12月住院及门诊就诊的89例肺炎患儿。其中轻度肺炎组52例，重度肺炎组37例；同期门诊体检健康的30例婴幼儿作为健康对照组。采用双抗体夹心免疫发光法定量测定各组血清降钙素原（PCT）水平，酶联免疫吸附法检测各组血清白细胞介素6（IL-6）、白细胞介素10（IL-10）、sTREM-1水平。结果轻度肺炎组患儿血清IL-6、IL-10、PCT水平较健康对照组升高，差异均有统计学意义（r=40．35、22．00、35．13，P均〈0．05）；重度肺炎组患儿血清IL-6、IL-10、PCT水平较健康对照组升高，差异均有统计学意义（χ^2=59．62、9．72、47．41，P均〈0．05）。轻度肺炎组与重度肺炎组患儿血清IL-6、IL-10、PCT水平比较差异均无统计学意义（r=4．20、2．07、2．39，P均〉0．05）。重度肺炎组血清IL-6／IL-10比值（5．65）高于轻度肺炎组（1．32）和健康对照组（0．80），差异均有统计学意义（χ^2=6．54、18．09，P均〈0．05）；重度肺炎组血清sTREM-1水平（117．78ng／L）高于轻度肺炎组（40．85ng／L）和健康对照组（12．12ng／L），差异均有统计学意义（χ^2=11．68、73．52，P均〈0．05）。血清IL-6／IL-10比值和sTREM-1呈正相关（r=0．51，P〈0．0001）。结论通过检测sTREM-1有助于判断婴幼儿社区获得性肺炎的严重程度。

作者郁志伟钱俊顾晓虹

机构地区无锡市儿童医院呼吸科

出处《中华实用儿科临床杂志》 CSCD 北大核心 2015年第22期1744-1745,共2页 Chinese Journal of Applied Clinical Pediatrics

基金无锡市社会发展计划指令性项目（CSE01N1109）

关键词可溶性髓系细胞触发受体-1 社区获得性肺炎婴幼儿

分类号 R725.6 [医药卫生—儿科]

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