摘要
目的探讨血清胃蛋白酶原（PG）、癌胚抗原（CEA）、糖蛋白抗原199（CAl99）及糖蛋白抗原724（CA724）水平与胃黏膜病变的关系，验证这些标志物用于胃癌诊断的性能。方法选取2013—01—2015—03扬州市第一人民医院接受胃镜检查并取病理活组织检查者为研究对象，共320例受试者测定血清PG水平、CEA、CA199及CA724水平，分析这些指标与胃黏膜病变的关系。结果与正常胃黏膜组相比，胃癌组各项指标均有不同。结论以上指标在胃癌筛查中具有重要的临床意义。血清PG水平与胃黏膜病变相关，胃癌患者血清中cEA、CA199及CA724显著高于良性病变组，可作为临床胃癌诊断的良好辅助标志。
OBJECTIVE To investigate the serum pepsinogen （PG）, carcinoembryonic antigen 199 （CA199） glyco- protein antigens and antigen of glycoprotein 724, CA724 levels and the relationship between gastric mucosal lesions, veri- fy the performance of these markers for gastric cancer diagnosis. METHODS Total of 320 subjects to determine serum PG level, CEA, CA199 and CA724 levels. To discuss the relationship between these indexes and pathological changes of gastric mucosa. RESULTS Compared with normal gastric mucosa research object, the indicators are different gastric cancer group. CONCLUSIONS The above index has important clinical significance in screening for gastric cancer. Serum PG level associated with gastric mucosal lesions, gastric cancer patients Serum CEA, CA199 and CA724 group signifi- cantly higher than that of benign lesions, and can be used as a good auxiliary examination method in clinical diagnosis of gastric cancer.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2015年第B22期176-178,共3页
Chinese Journal of Cancer Prevention and Treatment
