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RIP3-依赖性细胞坏死在脓毒症中研究进展 被引量：1

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摘要 脓毒症（sepsis）是一种严重感染引起的全身炎症反应[1-2],它可以被看作是从感染到多器官功能障碍综合征的持续恶化[3].在美国,脓毒症是重症监护病房中非心脏病死亡的首要原因,每年发病超过80万人,病死率高达30％[4],花费占美国总住院费的39％[5],但仍缺乏有效的治疗手段.脓毒症的致病机制尚不清楚,促炎和抗炎细胞因子失衡在脓毒症的发生和发展中起着重要作用.近年来研究发现,蛋白激酶3 （receptor interaction protein kinase 3,RIP3）-依赖性细胞坏死是这一过程的重要参与者.本文综述了RIP3参与的细胞坏死信号途径以及RIP3-依赖性细胞坏死在脓毒症中作用机制的研究进展.
作者 于璐 徐峰
机构地区 苏州大学附属第一医院急诊科
出处 《中华急诊医学杂志》 CAS CSCD 北大核心 2015年第11期1302-1305,共4页 Chinese Journal of Emergency Medicine
关键词 细胞坏死 脓毒症 依赖性 多器官功能障碍综合征 PROTEIN 全身炎症反应 重症监护病房 细胞因子失衡
分类号 R459.7 [医药卫生—急诊医学]
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参考文献34

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中华急诊医学杂志
2015年 第11期

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