摘要
目的分析原发性高血压患者血清及尿液中性粒细胞明胶酶相关脂质运载蛋白(NGAL)表达水平及其临床意义。方法对107例原发性高血压患者和100例健康者进行血清、尿NGAL检测和尿微量清蛋白检测。对检测结果进行统计学分析。结果原发性高血压患者血清、尿NGAL浓度分别为(1.98±1.49)、(1.29±0.54)μg/L,健康者血清、尿NGAL浓度分别为(0.69±1.02)、(0.55±0.35)μg/L,前者血清、尿NGAL水平均高于后者(P<0.05)。原发性高血压患者尿微量清蛋白水平高于健康者(P<0.05)。结论原发性高血压患者血清及尿液NGAL水平明显升高,为早期干预高血压性肾损伤提供了新的研究方向。
Objective To investigate the serum and urine levels of neutrophil gelatinase-associated lipocalin（NGAL）in patients with primary hypertension and related clinical significance.Methods A total of 107 patients with primary hypertension and 100 healthy subjects were enrolled,and detected for serum and urine levels of NGAL and urinary micro-albumin.Results Serum and urine levels of NGAL in hypertension patients were（1.98±1.49）and（1.29±0.54）μg/L,higher than the（0.69±1.02）and（0.55±0.35）μg/L in healthy subjects（P〈0.05）.Urinary micro-albumin level in hypertension patients was also higher than healthy subjects（P〈0.05）.Conclusion Serum and urine levels of NGAL in patients with primary hypertension could be significantly increased,which might be with important clinical significance in diagnosis,treatment and prognosis of hypertensive nephropathy.
出处
《国际检验医学杂志》
CAS
2015年第21期3090-3091,共2页
International Journal of Laboratory Medicine
基金
2011年盐城市科技立项(YK2011012)
