摘要
目的研究急性心肌梗死(AMI)患者经皮冠状动脉成形术后高敏C反应蛋白(hsCRP)、心肌肌钙蛋白I(cTnI)、脑钠肽(BNP)浓度与预后的关系。方法筛选2013年6月—2014年6月我科收治的急性心肌梗死并行经皮冠状动脉成形术和常规治疗的患者50例作为观察组(OG),同时筛选急性心肌梗死行内科药物治疗的患者50例作为对照组(CG)和非心肌梗死患者50例作为空白组(BG)。经皮冠状动脉成形术后1 d、7 d,分别检测3组患者静脉血中BNP、cTnI、hsCRP浓度。随访3组患者半年内的主要不良心脏事件,对比分析3组患者血浆指标及主要不良心脏事件。结果术后1 d,CG组和OG组患者静脉血中BNP、cTnI、hsCRP浓度均显著高于与BG组患者(P<0.01),但CG组患者和OG组患者的此3个血浆指标比较差异无统计学意义(P>0.05)。术后7d,CG组和OG组患者静脉血中BNP、cTnI、hsCRP浓度均仍显著高于与BG组患者(P<0.01)。CG组患者hsCRP浓度显著高于OG组患者[(12.9±4.1)mg/L vs(7.5±0.5)mg/L,P<0.01]。CG组患者BNP浓度显著高于OG组患者[(1 993±202)ng/L vs(331±30)ng/L,P<0.01]。CG组患者cTnI平均浓度显著高于OG组患者[(7.4±0.4)ng/L vs(2.6±0.2)ng/L,P<0.01]。CG组患者主要不良心脏事件发生率高于OG组患者(48.0%vs 18.0%,P<0.01)。结论对于急性心肌梗死患者,经皮冠状动脉成形术后内心肌肌钙蛋白I、高敏C反应蛋白、脑钠肽能够反映急性心肌梗死患者的预后程度。
Objective To investigate the relationship between the concentrations of brain natriuretic peptide （BNP）,high sensitivity C reactive protein （hsCRP）,cardiac troponin I （cTnI）and prognosis in patients with acute myocardial infarction（AMI）after percutane-ous transluminal coronary angioplasty（PTCA）.Methods Fifty patients with AMI after PTCA and conventional treatment which were conducted in our department from June 2013 to June 2014 were screened out and named as the observation group（OG）.Fifty pa-tients with AMI undergone simple conventional treatment were screened out and named as the control group （CG）.Fifty patients with un AMI treated by simple conventional treatment were screened out and named as the blank group （BG）.The concentrations of BNP,cTnI,hsCRP in three groups were measured in the 1st and 7th day after PTCA.The major adverse cardiac events （MACE）were observed within six months.Results The concentrations of plasma BNP,cTnI,hsCRP in CG and OG were significantly higher than that in BG after 1 day of PTCA（P〈0.01）.There was no significant difference in BNP,cTnI,hsCRP between CG and OG（P〉0.05）. The concentrations of plasma BNP,cTnI,hsCRP in CG and OG were significantly higher than that in BG after 7 days of PTCA（P〈0.01）.The concentrations of plasma hsCRP,BNP,cTnI in CG were significantly higher than that in OG [（12.9±4.1）mg/L vs （7.5±0.5） mg/L,（1 993± 202）ng/L vs （331± 30）ng/L,（7.4± 0.4）ng/L vs （2.6± 0.2）ng/L,P〈0.01].The incidence of MACE in CG was higher than that in OG（48.0% vs 18.0%,P〈0.01）.Conclusion The concentrations of plasma BNP,cTnI,and hsCRP can predict the prog-nosis in patients with AMI fol oning PTCA.
出处
《中西医结合心脑血管病杂志》
2015年第13期1514-1516,共3页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
急性心肌梗死
经皮冠状动脉腔内血管成形术
脑钠肽
acute myocardial infarction
percutaneous transluminal coronary angioplasty
brain natriuretic peptide
