摘要
目的观察应激诱导的心肌缺血发生时髓过氧化物酶(MPO)水平的变化。方法选取97例疑似冠状动脉疾病(CAD)患者行负荷心肌灌注显像(S-MPI),71例急性冠脉综合征(ACS)患者在入组前已接受经皮冠状动脉介入治疗,15位健康志愿者作为对照组。采用胶乳增强免疫比浊法对183例入组患者测定血浆MPO水平。对接受S-MPI的患者,在负荷试验前和负荷试验后测定MPO水平。结果 97例S-MPI患者中有48例被诊断为应激诱导的心肌缺血。应激诱导心肌缺血患者的MPO水平高于没有应激诱导心肌缺血患者(33±4ng/m L vs.24±4ng/m L,P=0.02),但未超过MPO参考值上限。ACS患者与S-MPI患者分别和正常人相比,MPO水平均显著升高(132±16ng/m L vs.29±3ng/m L,P<0.01),(132±16ng/m L vs.26±2ng/m L,P<0.01)。结论 S-MPI后没有增加血浆MPO水平,因此,MPO对于应激诱导的心肌缺血并不敏感。
Objective To investigate the changes of plasma myeloperoxidase （MPO）levels in patients when stress- induced myocardial ischemia occurs. Methods 97 cases of patients with coronary artery disease underwent stress myocardial perfusion imaging （S-MPI）, 71 cases of patients with acute coronary syndrome （ACS）received percutaneous coronary intervention and 15 healthy volunteers were selected in this study. The plasma MPO levels in patients and health controls were detected by latex enhanced immune turbidimetric method. Results 48 of 97 patients with S-MPI were diagnosed as stress-induced myocardial ischemia. The MPO levels of patients with stress- induced myocardial ischemia were significantly higher than that of the patients without stress induced myocardial ischemia （P 〈 0.05 ）, but it was not exceeding the maximum limitation, and the MPO level was not significantly changed after the load test. The MPO levels in ACS patients and S-MPI patients were significantly higher than that of controls （ P 〈 0.01 ）. Conclusion The plasma MPO level is not increased after loading S-MPI, so MPO is not a reliable marker for stress-induced myocardial ischemia.
出处
《标记免疫分析与临床》
CAS
2015年第10期1000-1003,1036,共5页
Labeled Immunoassays and Clinical Medicine
关键词
髓过氧化物酶
冠状动脉疾病
胶乳增强免疫比浊法
Myeloperoxidase
Acute coronary syndrome
Latex enhanced immunoturbidimetric method
