摘要
调节性T细胞(Treg)是重要的免疫调节功能细胞,叉头状p3因子(Foxp3)对Treg细胞的发育和功能调节至关重要。通常认为Foxp3+Treg细胞通过抑制效应T细胞功能从而削弱机体对肿瘤细胞的免疫反应,对肿瘤的发生发展有着密切的联系。这些细胞主要是肿瘤浸润性淋巴细胞(TIL)中的Foxp3+Treg细胞,其聚集在癌周的具体机制仍不清楚。然而,亦有认为Foxp3+Treg细胞可抑制肿瘤生长,Foxp3高表达与疾病的良好预后有关。笔者通过文献复习,分析结论相左的原因可能与胃癌类型、Foxp3检测抗体、Foxp3+Treg细胞亚型有关。因此,鉴定出具有稳定免疫抑制功能的Foxp3+Treg细胞亚型,分析各亚型与各类型胃癌之间的关系,才能得出更可靠的数据。
The regulatory T cells（Tregs） are important immunoregulatory cells and the forkhead box P3（Foxp3） is essential for the production and normal function of Tregs.It is generally believed that Foxp3~＋ Treg cells reduce immune response to tumor cells via inhibiting the function of T cells,and are closely associated with the genesis and development of tumors.These cells mainly pertain to Foxp3~＋ Treg cells in tumor infiltrating lymphocytes（TIL）,but the exact mechanism for their peritumor accumulation remains unclear.On the contrary,others insist that Foxp3~＋ Treg cells inhibit tumor growth,and high expression of Foxp3 in tumor is correlative to favorable prognosis of diseases.After literature review,the authors analyzed that the causes of the disagreement might be related to the distinct types of gastric cancer and antibody for detecting Foxp3 and the subpopulation of Foxp3~＋Treg cells.Therefore,more reliable data can be obtained only by identifying the true subtypes of Foxp3~＋ Treg cells and verifying their relations with the various types of gastric cancer.
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2015年第10期1451-1456,共6页
China Journal of General Surgery
基金
四川省科学技术厅科研专项基金资助项目(14JC0092)
关键词
胃肿瘤
叉头转录因子类
T淋巴细胞
调节性
综述文献
Stomach Neoplasms
Forkhead Transcription Factors
T-Lymphocytes
Regulatory
Review
