摘要
目的:评价术前NLR(中性/淋巴细胞)、D-NLR(间接中性/淋巴细胞)、PLR(血小板/淋巴细胞)和LMR(淋巴细胞/单核细胞)比值对结直肠癌患者预后的影响和预测价值。方法:回顾分析南京第一医院205例经过手术治疗的结直肠癌患者的临床资料及回访资料,采用受试者工作特征曲线区分高比值组和低比值组,并采用单因素和COX回归模型分析两组患者的NLR、D-NLR、PLR和LMR及其他临床病理因素与5年无复发生存率的关系。结果:根据ROC曲线,LMR的曲线下面积小于0.5,所以不能用作结直肠癌患者的预后诊断的指标;当NLR的截点为3.12时,对术后复发和预后的预测价值最高,同时在单因素分析中显示,NLR、D-NLR和PLR都对患者的无复发生存率有影响(P<0.05),多因素的回归分析中,NLR≥3.12和肿瘤分期是结直肠癌复发的独立危险因素。结论:术前NLR≥3.12是影响结直肠癌患者术后复发的独立危险因素,对患者的预后有预测价值。
Objective：To evaluate the impact and predictive value of neutrophil-to-lymphocyte ratio（ NLR） ,derived neutrophil-to-lymphocyte ratio（ d-NLR） ,platelet-to-lymphocyte ratio（ PLR） and lymphocyte-to-monocyte ratio（ LMR） on the prognosis of patients with colorectal cancer with curative resection.Methods： Retrospective analysis of 205 cases of clinical data and returning data after patients with colorectal cancer surgery,ROC curve was applied to determine thresholds for four biomarkers and their prognostic values were assessed using Kaplan-Meier curve,univariate and multivariate COX regression models of patients with NLR,D-NLR,PLR and LMR and other clinicopathological factors and the relationship between the 5-year recurrent-free survival（ RFS）.Results：According to the ROC curve,LMR could not be used as a potential diagnostic biomarker for subsequently analysis,for its AUC was less than 0.50, The optimal cut-off values were 3.12 with the highest specificity and sensitivity （ 75% and 73.1%） for NLR, while in the univariate analysis show,NLR,D-NLR and PLR were all risk factors of poor recurrence-free survival （ P〈0.05 ） , the multivariate regression analysis,NLR≥3.12 and colorectal cancer staging were independent risk factors of prognosis of colorectal cancer.Conclusion：NLR≥3.12 can provide improved accuracy for predicting clinical outcomes in surgical CRC patients under surgery resection.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2015年第10期1389-1393,共5页
Chinese Journal of Immunology
基金
江西省卫生计生委科技计划(No.20157141)
