摘要
目的:观察口服臭氧水联合常规胃四联疗法根除患者胃内幽门螺杆菌(Helicobacter pylori,H.pylori)的效果及不良反应.方法:收集2013-10/2015-04中国人民武装警察8710部队医院经^(13)C-尿素呼气试验证实H.pylori阳性患者200例,随机分为臭氧水+胃四联组(口服臭氧水,2次/d,共15d,奥美拉唑20 mg+阿莫西林1000 mg+克拉霉素500 mg+构橼酸铋钾220 mg,2次/d,共10 d),胃四联组(奥美拉唑20 mg+阿莫西林1000 mg+克拉霉素500 mg+枸橼酸铋钾220 mg,2次/d,共10 d).疗程结束后4 wk行^(13)C-尿素呼气试验检测H.pylori根除效果,并记录药物不良反应发生率.结果:200例患者均完成随访,臭氧水+胃四联组与胃四联组H.pylori根除率按意向治疗(intention to treat,ITT)分析分别为91.0%(91/100)、80.0%(80/100),按方案治疗(per protocol,PP)分析分别为93.8%(91/97)、81.6%(80/98)(P<0.05).臭氧水+胃四联组与胃四联组恶心呕吐、腹泻、腹胀的发生率分别为4.0%(4/100)比13.0%(13/100),4.0%(4/100)比8.0%(8/100),6.0%(6/100)比8.0%(8/100),其中两组恶心呕吐发生率比较差异有统计学意义(P<0.05).结论:臭氧可以有效提高常规四联疗法根除H.pylori的疗效,并降低药物治疗所产生的不良反应发生率.
AIM：To explore the effect of ozone water therapy on efficacy and adverse reactions of standard quadruple therapy for Helicobacter pylori（H.pylori） infection.METHODS：From October 2013 to April 2015,200 patients with H.pylori infection were collected and equally divided into an ozone water therapy with standard quadruple therapy group and a standard quadruple therapy alone group.Each group received omeprazole 20 mg,amoxicillin 1000 mg,clarithromycin 500 mg and bismuth potassium citrate 220 mg twice daily for 10 d,and the combination group additionally received ozone water twice daily for 15 d.At 4 wk after the end of therapy,the patients underwent the ^13C-urea breath test.The negative result indicated successful H.pylori eradication.Adverse reactions were also recorded during treatment.RESULTS：All the 200 patients completed the follow-up.According to intention to treat（ITT） analysis,the eradication rates for the two groups were 91.0%（91/100） and 80.0%（80/100）,respectively.According to per protocol（PP）analysis,the rates were 93.8%（91/97） and 81.6%（80/98）,respectively.The differences in the eradication rates between the two groups were statistically significant（P〈0.05）.The rates of nausea,vomiting,diarrhea and abdominal bloating for the two groups were 4.0%（4/100）us 13.0%（13/100）,4.0%（4/100） us 8.0%（8/100）,6.0%（6/100） us 8.0%（8/100）.The differences in the rates of nausea and vomiting between the two groups were statistically significant（P〈0.05）.CONCLUSION：Ozone can improve the efficacy of standard quadruple therapy for H.pylori eradication,and reduce the rates of adverse reactions during treatment.
出处
《世界华人消化杂志》
CAS
2015年第26期4284-4288,共5页
World Chinese Journal of Digestology
基金
湖南省自然科学基金资助项目
No.2014SK3168~~
关键词
幽门螺杆菌
臭氧
不良反应
Helicobacter pylori
Ozone
Adverse reactions
