摘要
目的 探讨丙泊酚治疗难治性癫痫持续状态（RSE）的疗效及安全性。方法 计算机检索CBM（1985~2014.7）、Wan Fang Data（1982~2014.7）、VIP（1989~2014.7）、CNKI（1979~2014.7）、Pub Med（1966~2014.7）、Embase（1974~2014.7）,根据纳入、排除标准选择有关丙泊酚治疗RSE的对照试验,并提取有效数据,采用Rev Man 5.3软件进行分析。结果 共纳入5个有效研究,合计111例患者。Meta分析结果显示,丙泊酚组治疗RSE的癫痫控制率总体上优于对照组（OR=2.44,95%CI：1.05~5.66,P=0.04）,但二者死亡率的差异无统计学意义（OR=1.19,95%CI：0.55~2.61,P=0.66）。结论 丙泊酚可有效控制RSE发作,但并不降低其死亡率。
Objective To evaluate the efficacy and safety of propofol for refractory statue epilepticus（ RSE）.Methods Controlled trials associated with RSE were searched from the database of CBM（ 1985- 2014. 7）,Wan Fang（ 1982- 2014. 7）,VIP（ 1989- 2014. 7）,CNKI（ 1979- 2014. 7）,Pub Med（ 1966- 2014. 7）,Embase（ 1974- 2014. 7）,and the related references were picked up by inclusion and exculsion criteria and traced to obtain the information. Meta-analysis was performed using Rev Man 5. 3 software. Results Totally 5 studies involving 111 patients were included. Meta-analysis showed that the epilepsy control rate of propofol group on treating RSE was significantly more effective than control group（ OR = 2. 44,95% CI： 1. 05- 5. 66,P = 0. 04）. However,the mortality was no statistical difference（ OR = 1. 19,95% CI： 0. 55- 2. 61,P = 0. 66）. Conclusion Propofol is effective to control RSE,but can not reduce its mortality rate.
出处
《临床神经病学杂志》
CAS
北大核心
2015年第5期338-340,共3页
Journal of Clinical Neurology
