摘要
目的:评价前期制定的中药内服方案治疗寻常型银屑病的临床疗效及安全性。方法:轻度银屑病患者被辨证分为血热证组、血燥证组和血瘀证组,每个证型均入组120例,按2∶1比例随机分为中药内服治疗组和安慰剂对照组,疗程8周,采用PASI评分改善率作为评价标准。结果:统计病例350例,中药内服治疗组在血热证组的总有效率为69.23%,血燥证组的总有效率为67.09%,血瘀证组的总有效率为56.41%,但只有在血燥证组中中药内服治疗组优于安慰剂对照组(P<0.05)。中药内服治疗组与安慰剂对照组均无严重不良反应发生。结论:中药内服治疗寻常型银屑病安全、有效,但不同证型的疗效不相同。
Objective：To evaluate the clinical efficacy and safety of Chinese herbal medicine in the treatment of psoriasis vulgaris.Methods：Mild psoriasis patients were differentiated into blood-heat syndrome group,blood-dryness syndrome group and blood-stasis syndrome group,120 patients were recruited in each group,and randomized 2：1 to receive Chinese herbs or placebo.The primary endpoint was the proportion of patients achieving improvement in Psoriasis Area and Severity Index（PASI 75） at week 8.Results：Three-hundred and fifty cases were analyzed.The total effective rate of Chinese herbs prescription in blood-heat syndrome group was 69.23%,blood-dryness was 67.09% and blood-stasis group was 56.41%,and only in blood-dryness group it was higher than placebo statistically（P〈0.05）.No severe side-effect occurred in all patients.Conclusion：Chinese herbs in treating mild psoriasis are effective and safe,but the effects are distinct in different syndrome.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2015年第10期3614-3618,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
北京市科技计划项目(No.D09050703550901
No.Z151100004015240)
国家自然科学基金项目(No.81273766)~~
关键词
寻常型银屑病
血热证
血燥证
血瘀证
凉血解毒汤
养血解毒汤
活血解毒汤
多中心随机对照研究
Psoriasis vulgaris
Blood-heat syndrome
Blood-dryness syndrome
Blood-stasis syndrome
Liangxue Jiedu Decoction
Yangxue Jiedu Decoction
Huoxue Jiedu Decoction
Multicenter and randomized control trial
