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Piroxicam-mediated modulatory action of 5-hydroxytryptamine serves as a “brake” on neuronal excitability in ischemic stroke 被引量：4

Piroxicam-mediated modulatory action of 5-hydroxytryptamine serves as a “brake” on neuronal excitability in ischemic stroke
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摘要 Our previous studies indicated an increase in extracellular y-aminobutyric acid （GABA） in rodent＇s ischemic brain after Piroxicam administration, leading to alleviation of glutamate me- diated excitotoxicity through activation of type A GABA receptor （GABAA）. This study was to investigate if GABAA activation by Piroxicam affects extracellular 5-hydroxytryptamine or not. High performance liquid chromatography revealed that there was a significant decrease in extracellular 5-hydroxytryptamine release in ischemic cerebral cortex and striatum in Piroxicam pre-treated rat brains. This suggests a probable role of Piroxicam in reducing extracellular 5-hy- droxytryptamine release in ischemic cerebral cortex and striatum possibly due to the GABAA activation by Piroxicam. Our previous studies indicated an increase in extracellular y-aminobutyric acid （GABA） in rodent＇s ischemic brain after Piroxicam administration, leading to alleviation of glutamate me- diated excitotoxicity through activation of type A GABA receptor （GABAA）. This study was to investigate if GABAA activation by Piroxicam affects extracellular 5-hydroxytryptamine or not. High performance liquid chromatography revealed that there was a significant decrease in extracellular 5-hydroxytryptamine release in ischemic cerebral cortex and striatum in Piroxicam pre-treated rat brains. This suggests a probable role of Piroxicam in reducing extracellular 5-hy- droxytryptamine release in ischemic cerebral cortex and striatum possibly due to the GABAA activation by Piroxicam.
作者 Pallab Bhattacharya Anand Kumar Pandey Sudip Paul Ranjana Patnaik
机构地区 Department of Neurology School of Biomedical Engineering Department of Biomedical Engineering
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第9期1418-1420,共3页 中国神经再生研究（英文版）
关键词 nerve regeneration ischemic stroke SEROTONIN y-aminobutyric acid NEUROPROTECTION PIROXICAM cerebral cortex STRIATUM nerve regeneration ischemic stroke serotonin y-aminobutyric acid neuroprotection piroxicam cerebral cortex striatum
分类号 R743.3 [医药卫生—神经病学与精神病学]
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  • 1Bhattacharya P, Pandey AK, Paul S, Patnaik R (2014) Alleviation of glutamate mediated neuronal insult by piroxicam in rodent model of focal cerebral ischemia: a possible mechanism of GABA agonism. J Physiol Biochem 70:901-913.
  • 2Bhattacharya P, Pandey AK, Paul S, Patnaik R, Yavagal DR (2013) Aquaporin-4 inhibition mediates piroxicam-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rodents. PLoS One 8:e73481.
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Neural Regeneration Research
2015年 第9期

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