期刊文献+

外周多巴胺与肿瘤

原文传递
导出
摘要 多巴胺是一类重要的儿茶酚胺类神经递质,通过多巴胺受体(DRs)作用于中枢神经系统,对认识、情感、肢体运动起重要调节作用,同时作为一种神经内分泌激素,也可作用于外周组织,主要调节外周血管张力以及心肾功能.近年来,研究发现DRs多态性与肿瘤发生风险相关,且多种肿瘤细胞、肿瘤血管内皮及免疫细胞均可表达DRs.本文就外周多巴胺与肿瘤的研究进展作如下阐述.
出处 《中华医学杂志》 CAS CSCD 北大核心 2015年第36期2983-2985,共3页 National Medical Journal of China
基金 国家自然科学基金(81272573)
  • 相关文献

参考文献27

  • 1Peters MA, Walenkamp AM, Kema IP, et al. Dopamine and serotonin regulate tumor behavior by affecting angiogenesis [ J 1. Drug Resist Updat, 2014, 17(445) :96-104.
  • 2Beaulieu JM, Gainetdinov RR. The physiology, signaling, and pharmacology of dopamine receptors [ J ]. Pharmacol Rev, 2011, 63(1) :182-217.
  • 3Lalonde FM, Myslobodsky M. Are dopamine antagonists a risk factor for breast cancer? an answer from Parkinson's disease [ J ]. Breast, 2003, 12(4) :280-282.
  • 4Lin GM, Chen YJ, Kuo DJ, et al. Cancer incidence in patients with schizophrenia or bipolar disorder: a nationwide population- based study in Taiwan, 1997-2009 [ J ]. Schizophr Bull, 2013,39 (2) :407-416.
  • 5Bushe C J, Bradley AJ, Wildgust HJ, et al. Schizophrenia and breast cancer incidence: a systematic review of clinical studies [J]. Schizophr Res, 2009,114(1-3) :6-16.
  • 6Ji J, Sundquist K, Ning Y, et al. Incidence of cancer in patients with schizophrenia and their first-degree relatives: a population- based study in Sweden [ J]. Schizophr Bull, 2013,39 ( 3 ) : 527- 536.
  • 7Campa D, Zienolddiny S, Lind H, et al. Polymorphisms of dopamine receptor/transporter genes and risk of non-small cell lung cancer[J]. Lung Cancer, 2007,56( 1 ) :17-23.
  • 8Murphy G, Cross AJ, Sansbury LS, et al. Dopamine D2 receptor polymorphisms and adenoma recurrence in the Polyp Prevention Trial[J3. Int J Cancer, 2009,124(9) :2148-2151.
  • 9Chakroborty D, Chowdhury UR, Sarkar C, et at. Dopamine regulates endothelial progenitor cell mobilization from mouse bone marrow in tumor vascularization [ J ]. J Clin Invest, 2008, 118 (4) :1380-1389.
  • 10Chakroborty D, Sarkar C, Mitra RB, et al. Depleted dopamine in gastric cancer tissues : dopamine treatment retards growth of gastric cancer by inhibiting angiogenesis[ J]. Clin Cancer Res, 2004,10 (13) :4349-4356.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部