摘要
目的:观察逍遥丸联合四逆散治疗产后抑郁的临床疗效及安全性。方法:将入选研究的110例产后抑郁患者随机分为2组,对照组55例单用逍遥丸治疗,治疗组55例采用逍遥丸联合四逆散治疗,治疗时间均为4周,治疗结束后评价临床效果及不良反应情况。结果:治疗组总有效率92.73%,显著高于对照组的74.55%,2组比较,差异有统计学意义(P<0.05)。2组治疗1周、4周后汉密尔顿抑郁量表(HAMD)评分均较本组治疗前减少,差异均有统计学意义(P<0.05),且2组比较,差异均有统计学意义(P<0.05)。治疗组不良反应量表(TESS)评分为(2.55±1.20)分,对照组TESS评分为(3.10±0.93)分,2组比较,差异有统计学意义(P<0.05)。结论:逍遥丸联合四逆散治疗产后抑郁效果显著,安全性高,明显优于单用逍遥丸治疗。
Objective： To explore the clinical efficacy and safety of Sini San combined with Xiaoyao Wan in treatmenting postpartum depression. Methods： One hundred and ten cases of patients with postpartum depression were selected and were randomly divided into two groups. Fifty-five cases in the control group were treated with Xiaoyao Wan, and 55 cases in the observation group were given Sini San combined with Xiaoyao Wan for 4 weeks of treatment. The clinical effect and adverse reaction after treatment were compared. Results： The total effective rate of the observation group was 92.73%, and was significantly higher than 74.55% of the control group（P 〈 0.05）. The scores of Hamilton rating scales for depression （HAMD） were decreased after 1-week and 4-week treatment （P 〈 0.05 compared with before treatment）. The differences between the two groups after treatment were significant（P 〈 0.05）. The scores of treatment emergent symptom scale（TESS） in the treatment group were（2.55 ＋ 1.20） points, while in the control group were（3.10_＋0.93） points, the difference being significant（P 〈 0.05）. Conclusion： Sini San combined with Xiaoyao Wan has a significant effect and high safety in treatmenting postpartum depression, which is better than the single use of Xiaoyao Wan.
出处
《新中医》
CAS
2015年第10期120-122,共3页
New Chinese Medicine
