摘要
目的探讨肛管直肠恶性黑色素瘤的临床病理特征。方法收集7例肛管直肠恶性黑色素瘤的临床病理资料并随访,分析其临床和病理组织学特征和免疫表型。结果本例中包含女性5例,男性2例,年龄50~68岁,平均61岁。肿瘤位于直肠下端1例,齿线附近2例,肛管肛缘4例。该肿瘤组织结构和细胞形态有多样性。组织结构上主要为弥漫片状、巢状、腺泡状。细胞形态主要为上皮样、梭型细胞样、淋巴细胞样。免疫组织化学检测显示肿瘤细胞HMB45、S-100和vimentin强阳性,LCA、CK和EMA均阴性,其中2例CEA灶性阳性,Ki-67 LI为20%~50%。结论肛管直肠恶性黑色素瘤是少见的恶性肿瘤,其特征性的组织形态、免疫表型有助于诊断和鉴别诊断。
Objective To investigate the clinical and pathological features of anorectal malignant melanoma （AMM）. Methods The clinical pathological and follow-up data of 7 cases of anorectal malignant melanoma were collected. The clinical and histopathological features and immunophenotype were analyzed. Results Among the 7 cases, 5 cases were female, 2 cases were male, aged 50 -68 years, the average was 61 years. The tumors located in the lower rectum in 1 cases, 2 cases of teeth near the line, 4 cases of anal anus. The structure and morphology of the cancer cells were diverse. The organizational structures were mainly diffuse, focal and acinar. The cellular morphologies were mainly epithelioid, spindle and lymphocyte like. And the results of IHC showed the expression of the following three markers, vimentin, S-100 and HMB45, were strongly positive in cancer cells. However, the expression of CK, EMA and LCA were negative. And 2 cases of CEA expression were positive, LI Ki-67 was 20% -50%. Conclusions Anorectal malignant melanoma is one kind of rare malignant tumor and its characteristic morphology, immunophenotype could be helpful for diagnosis and differential diagnosis.
出处
《基础医学与临床》
CSCD
2015年第9期1252-1255,共4页
Basic and Clinical Medicine
基金
湖北省自然科学基金(2013CFB374)
关键词
肛管直肠
恶性黑色素瘤
临床病理特征
免疫组化
鉴别诊断
anorectal malignant melanoma
clinicopathologic features
immunohistochemistry
differential diagnosis
