摘要
[目的]探讨胃pH联合胆红素监测诊断十二指肠胃反流(duodenogastric reflux DGR)的应用价值。[方法]对慢性胃炎组90例、对照组20例分别进行胃镜及组织学检查、总胆汁酸测定、核素显像、胃pH联合胆红素监测诊断DGR,并进行对比性分析。[结果]对照组DGR(+)检出情况:胃pH联合胆红素监测检出率0%(0/20),与胃镜及组织学检查30%(6/20)比较,差异有统计学意义(P<0.01),与其他检查比较差异无统计学意义(P>0.05)。慢性胃炎组DGR(+)检出情况:胃pH联合胆红素监测53.3%(48/90),与胃镜及组织学检查76.7%(69/90)比较,差异有统计学意义(P<0.01),与其他检查比较差异无统计学意义(P>0.05)。以核素显像检查作为标准,其他3种检查方法对慢性胃炎组检测DGR准确性的比较,胃镜及组织学检查62.2%,差异有统计学意义(P<0.01),总胆汁酸测定81.1%,差异有统计学意义(P<0.05),胃pH联合胆红素监测90.0%,差异无统计学意义(P>0.05)。[结论]胃pH联合胆红素监测是诊断DGR最准确的方法,值得推广应用。
[Objective]To explore application value of combined gastric pH and bilirubin monitoring in the diagnosis of pathologic duodenogastric reflux（DGR）.[Methods]In this study,we randomly included 90 patients with gastritis and 20 controls.For detection of DGR,all subjects underwent gastroscopy and histological examination,total bile acid test,radionuclide imaging,gastric pH and bilirubin monitoring.A comparative analysis was then performed between the two groups.[Results]①In the control group,comparing with the positive rate of DGR diagonosed by gastroscopy and histological examination（30%,6/20）,the positive rate diagnosed by combined gastric pH and bilirubin monitoring was 0%（0/20）,which was statistical significance（P〈0.01）,although no statistical significance was observed between combined gastric pH and bilirubin monitoring and other examinations（P 〉0.05）.②In the gastritis group,comparing with the positive rate of DGR diagnosed by gastroscopy and histological（76.7%,69/90）,the positive rate of DGRdi-agnosed by combined gastric pH and bilirubin monitoring was 53.3%（48/90）,which was statistical significance（P〈 0.01）,although no was observed between combined gastric pH and bilirubin monitoring and other examinations（P〉 0.05）.③Considering the positive diagnosis by radionuclide imaging examinations as 100%,the accuracy rates of detection of DGR by gastroscopy and histological examination was 62.2%,total bile acid test was 81.1%,which were all statistical significance（P 〈0.01,P〈 0.05）.There was no significant difference between combined gastric pH and bilirubin monitoring（90.0%）and radionuclide imaging（P〉 0.05）.[Conclusion]Combined gastric pH and bilirubin monitoring is an accurate method for diagnosis of DGR.
出处
《临床消化病杂志》
2015年第4期204-208,共5页
Chinese Journal of Clinical Gastroenterology
关键词
十二指肠胃反流
PH监测
胆红素监测
核素显像
总胆汁酸测定
胃镜
胆汁反流
duodenogastric reflux
pH monitoring
bilirubin monitoring
radionuclide imaging
Total bile acid test
gastroscopy
bile reflux
