摘要
目的探讨通心络胶囊对早期糖尿病肾病(DN)患者血管内皮功能及肾功能的影响。方法选择2012年4月一2013年6月住院的DN患者100例,按照随机数字表法分为对照组和观察组各50例,2组患者均注射胰岛素降糖、他汀类降脂药及硫酸氢氯吡格雷等常规基础药物治疗,观察组在常规治疗基础上加服通心络胶囊。2组均治疗12周。观察治疗前后2组患者血管内皮功能及肾功能的变化。结果治疗前2组患者血管内皮功能及肾功能比较差异无统计学意义(P>0.05)。与治疗前比较,治疗后2组患者血管内皮生长因子(VEGF)、一氧化氮(NO)均升高(t_对=1.878、1.934;t_观=1.971、1.952,P均<0.05),内皮素-1(ET-1)、血肌酐(SCr)、尿素氮(BUN)、肌酐清除率(CCr)、胱抑素-C(Cys-C)、肿瘤坏死因子-α(TNF-α)均降低(t_对=1.846、1.792、1.813、1.885、1.861、1.916;t_观=1.891、1.808、1.900、2.034、2.012、1.978,P均<0.05)。与对照组治疗后比较,观察组VEGF、NO、均明显升高(t=2.265、3.348,P均<0.05),ET-1、SCr、BUN、CCr、Cys-C、TNF-α均明显降低(t=2.461、2.267、2.166、2.413、2.201、2.332,P均<0.05)。结论通心络胶囊能明显改善DN患者肾功能、血管内皮功能,降低体内炎性因子水平。
Objective To investigate the effect of Tongxinluo capsule on vascular endothelial function and renal func-tion in patients with early diabetic nephropathy （DN）.Methods From April 2012 to June 2013, 100 cases of DN patients were divided into control group and observation group , 50 cases in each group , according to random number table , 2 groups of patients were given insulin hypoglycemic , statin and Clopidogrel Hydrogen Sulfate and other conventional treatment , observa-tion group on the basis of routine treatment , also added Tongxinluo capsule.Two groups were treated for 12 weeks.The chan-ges of vascular endothelial function and renal function were observed before and after treatment .Results Before treatment , 2 group patients ’ vascular endothelial function and renal function ’ s differences did not show statistical significance （ P 〉0.05）.After treatment, two groups of patients ’ vascular endothelial growth factor （ VEGF）, nitric oxide （ NO） were in-creased （control group：t =1.878,1.934,observation group：t =1.971,1.952, P 〈0.05）, endothelin 1 （ET-1）, serum creatinine （SCr） and blood urea nitrogen （BUN）, creatinine clearance rate （CCR） and cystatin C （Cys C）, tumor necrosis factor alpha （TNF-α） were decreased （control group：t =1.846,1.792,1.813,1.885,1.861,1.916,observation group：t =1.891,1.808,1.900,2.034,2.012,1.978, P 〈0.05）.Compared with the control group, observation group’s vascular en-dothelial growth factor （VEGF）, nitric oxide （NO） were significantly increased （ t =2.265,3.348, P 〈0.05）, and ET-1, SCr, BUN, CCR, Cys C, TNF alpha were significantly reduced （ t =2.461,2.267,2.166,2.413,2.201,2.332, P 〈0 .05）.Conclusion It demonstrated that the Tongxinluo capsule could obviously improve the DN patients ’ renal function, vascular endothelial function , reduce inflammatory factor levels .
出处
《疑难病杂志》
CAS
2015年第9期884-887,共4页
Chinese Journal of Difficult and Complicated Cases
关键词
通心络胶囊
糖尿病肾病
血管内皮功能
肾功能
胱抑素
肿瘤坏死因子
Tongxinluo capsule
Diabetic nephropathy
Vascular endothelial function
Renal function
Cystatin C
Tumor necrosis factor
