摘要
目的基于文献分析中医外治法治疗化疗性周围神经病变的用药规律。方法检索中文生物医学文献数据库、中国期刊全文数据库和万方数据库2005年1月至2014年12月中医外治法治疗化疗性周围神经病变临床研究文献,建立化疗性周围神经病变中医外治用药数据库,统计药物使用频次,并对药物分类、功效、性、味、归经等进行描述性分析。结果共纳入文献35篇,涉及方剂35首,药物64味,共计290频次。64味药物按功效可分11类,其中使用频率最高的是活血祛瘀药(34.83%),其次是祛风湿药(18.62%)、解表药(11.72%)、温里药(11.03%)、补气药(8.28%)、补血药(7.93%);使用频数≥5的药物共17味,前10位依次为桂枝、红花、川芎、当归、黄芪、威灵仙、鸡血藤、赤芍、伸筋草、附子;药性使用频率最高的是温性(39.06%),温、微温、热性3类药物累积频率为51.56%;药味使用频率最高的是辛味(38.00%),辛、甘、微甘3类药物累积频率为58.00%;归经频率最高的是肝经(32.39%),其次是脾经(15.49%)、肺经(12.68%)。结论中医外治法治疗化疗性周围神经病变以益气、活血、化瘀、温阳、通络为基本用药原则,临床常用活血祛瘀、祛风湿、温里、补气补血等辛温行散之品。
Objective To analyze medication principles of Chinese medicine external therapies treating chemotherapeutic peripheral neuropathy based on published literature. Methods Review all published literature of clinical research about Chinese medicine external therapies treating chemotherapeutic peripheral neuropathy from Chinese Biology Literature Database,Journal Full-Text Database of China National Knowledge Infrastructure and Wanfang Data from January of 2005 to December of 2014. Establish database of Chinese medicine external therapies treating chemotherapeutic peripheral neuropathy. Make statistics of the frequency of herbs applied. Make descriptive analysis of herbs＇ type,effect,property,flavor channel tropism,etc. Results A total of 35 papers were included,35 prescriptions involved,64 herbs. The frequency was 290 in total,and 64 herbs were classified into 11 types according to effect. The most frequent herbs applied were herbs of activating blood and removing stasis（ 34. 83%）; more frequent herbs were herbs of dispelling wind and dampness（ 18. 62%）,relieving the exterior（ 11. 72%）,warming interior（ 11. 03%）,invigorating Qi（ 8. 28%） and invigorating blood（ 7. 93%）. Herbs which frequency were more than 5were 17. Top ten were Guizhi（ Cassia Twig）,Honghua（ Carthamus tinctorius）,Danggui（ Angelica sinensin）,Huangqi（ Astragalus mongholicus）,Weilingxian（ radix clematidis）,Jixueteng（ lignum millettiae）,Chishao（ radix paeoniae rubrathe）,Shenjincao（ lycopodium clavatum） and Fuzi（ radix aconiti carmichaeli）. The most frequent herb property applied was warm（ 39. 06%）. Total frequency of warm,slightly warm and hot herbs was 51. 56%. The most frequent herb flavor applied was pungent（ 38. 00%）. Total frequency of pungent,sweet and slightly sweet herbs was 58. 00%. The most frequent herb channel tropism applied was Liver Meridian（ 32. 39%）; second was Spleen Meridian（ 15. 49%）; third was Lung Meridian（ 12. 68%）. Conclusion The basic medication principles were supplementing Qi,activating blood,removing stasis,warming Yang and dredging collaterals in Chinese Medicine external therapies treating chemotherapeutic peripheral neuropathy. Pungent,warm,promoting and dispelling herbs,which could activate blood,remove stasis,dispel wind and dampness,warm interior and invigorate Qi and blood,were commonly applied clinically.
出处
《中医杂志》
CSCD
北大核心
2015年第17期1509-1512,共4页
Journal of Traditional Chinese Medicine
基金
国家"十二五"科技支撑计划(2012BAJ18B05)
北京市中医药科技发展项目(JJ2014-52)
北京市科技计划(D131100002213004)
关键词
周围神经病变
中医外治法
用药规律
文献分析
peripheral neuropathy
Chinese medicine external therapy
medicine principles
literature analysis
