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乙酰胆碱受体抗体及肌肉特异性受体酪氨酸激酶抗体均阳性的重症肌无力1例报告 被引量:3

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摘要 重症肌无力(MG)是一种累及神经-肌肉接头处乙酰胆碱受体(AchR)的自身免疫性疾病。约80%的MG患者血清AchR-Ab(+),但约20%的患者为阴性,称为血清阴性MG(SNMG)[1]。目前国内将肌肉特异性受体酪氨酸激酶抗体(Mu SK-Ab)阳性的MG归类于SNMG,乙酰胆碱受体抗体(AchR-Ab)及Mu SK-Ab同时阳性的重症肌无力尚无报道。
作者 崔伟
出处 《临床神经病学杂志》 CAS 北大核心 2015年第4期258-258,261,共2页 Journal of Clinical Neurology
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参考文献5

  • 1王中魁,魏东宁.肌肉特异性酪氨酸激酶抗体与重症肌无力[J].中国神经免疫学和神经病学杂志,2009,16(6):442-444. 被引量:4
  • 2Hoch W, McConville J, Helms S, et al. Auto-antibodies to the recep- tor tyrosine kinsse MuSK in patients with myasthenia gravis,without acetylcholine receptor antibodies [ J ]. Nat Med, 2001,7 : 365.
  • 3Ohta K, Shigemoto K, Kubo S, et al. MuSK antibodies in AchR Abseropositive MG vs AchRAb-sernegative MG [ J 1. Neurology, 2004, 62: 2132.
  • 4Spengos K, Vassilopoulou S, Papadimas G, et al. Dropped head syndrome as prominent clinical feature in MuSK-positive myasthenia gravis with thymus hyperplasia [ J 1. Neuromuscul Disord, 2008, 18 : 175.
  • 5Pasnoor M, Wolfe GI, Nations S, et al. Clinical findings in Musk- antibodypositive myasthenia gravis : a U. S. experience [ J 1. Muscle Nerve, 2010, 41 : 370.

二级参考文献17

  • 1Burden SJ. Building the vertebrate neuromuscular synapse[J]. J Neurobiol, 2002, 53:501-511.
  • 2Misgeld T, Kummer TT, Lichtman JW, etal. Agrin promotes synaptic differentiation by counteracting an inhibitory effect of neurotransmitter[J]. Proe Natl Acad Sci USA, 2005,102 : 11088-11093.
  • 3Ngo ST, Noakes PG, Phillips WD. Neural agrin: a synaptic stabiliser[J]. Int J Biochem Cell Biol,2007, 39:863- 867.
  • 4Shigemoto K, Kubo S, Maruyama N, etal. Induction of myasthenia by immunization against muscle-specific kinase[J]. J Clin Invest, 2006,116 :1016-1024.
  • 5Cole RN, Reddel SW, Gervasio OL, et al. Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction[J]. Ann Neurol, 2008,63 : 782-789.
  • 6McConville J, Farrugia ME, Beeson D, et al. Detection and characterization of MuSK antibodies in seronegative myasthenia gravis[J]. Ann Neurol, 2004,55: 580-584.
  • 7Vincent A, Bowen J, Newsom-Davis J, etal. Seronegative generalized myasthenia gravis: clinical features, antibodies, and their targets[J]. Lancet Neurol, 2003,2:99-106.
  • 8Yeh JH, Chen WH, Chiu HC, et al. Low frequeney of MuSK antibody in generalized seronegative myasthenia gravis among Chinese [J]. Neurology, 2004, 52:1920-1921.
  • 9Ohta K, Shigemoto K, Fujinami A. Clinical and experimental features of MuSK antibody positive MG in Japan[J]. Eur J Neurol, 2007,14 : 1029-1034.
  • 10Kostera-Pruszczyk A, Kaminska A, Dutkiewicz M, et al. MuSK-positive myasthenia gravis is rare in the Polish population[J].Eur J Neurol, 2008, 15:720- 724.

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