摘要
目的:探讨当归四逆汤联合米非司酮在子宫内膜异位症(EMS)患者术后治疗的最佳剂量。方法:随机将110例行手术治疗的EMS患者随机分为5组,每组各22例。分别是KB组(空白组),D1组(单纯5mg米非司酮)、D2组(单纯当归四逆汤)、G1组(5mg米非司酮+当归四逆汤)和G2组(10mg米非司酮+当归四逆汤)。比较各组治疗前后血清性激素、CA125水平的变化,临床缓解率、复发率和不良反应情况等。结果:G1和G2组完全缓解率显著高于D1和D2组(P<0.05),而复发率均显著低于KB组(P<0.05);G1和G2组CA125水平显著高于D1和D2组(P<0.05);G1和G2组P、E2水平显著低于D1和D2组(P<0.05);G1和G2间完全缓解率、复发率和CA125、P、E2水平差异均无统计学意义(均P>0.05)。结论:使用低剂量(5mg)米非司酮联合中药四逆汤治疗行手后的EMS患者,疗效确定,医疗费用更低廉,综合应用价值更优。
Objective：To investigate effects of different does of Danggui Sini decoction combing with mifepristone as postoperative treatment for endometriosis patients undergoing surgery.Methods：A total of 110 EMS patients underwent operation treatment were randomly divided into to 5groups with 22 cases in each group,including KB group（blank group）,D1group（5mg mifepristone group）,D2group（Danggui Sini decoction group）,G1group（mifepristone＋5mg Danggui Sini decoction group）and G2group（10mg mifepristone＋ Danggui Sini decoction group）.Changes in serum sex hormone,CA125 levels before and after treatment,the clinical remission rate,relapse rate and adverse reaction conditions were compared.Results：The complete remission rate of the G1 and G2groups were significantly higher,but the recurrence rate were lower than that of the D1 and D2groups（P〈0.05）.The CA125 levels of G1 and G2groups were significantly higher than that of D1 and D2groups（P〈0.05）.P and E2 levels of the G1 and G2groups were significantly lower than that of the D1 and D2groups（P〈0.05）.No significant difference in complete remission rate,recurrence rate,nor CA125,P,E2 levels were found between group G1 and G2.Conclusions：Small dose of mifepristone（5mg）combining with Danggui Sini decoction is an effective postoperative treatment for endometriosis patients undergoing surgery.It＇s economical and has higher comprehensive value.
出处
《海南医学院学报》
CAS
2015年第9期1248-1250,共3页
Journal of Hainan Medical University
基金
湖北省卫生厅(鄂卫2010-110020)~~
