摘要
目的：研究阿尔茨海默病患者定量脑电图检测结果及其与血清学指标的相关性。方法：将2012年5月~2014年8月期间我院门诊确诊的50例阿尔茨海默病患者纳入研究的观察组,将同期在我院体检的健康者纳入研究的对照组,进行定量脑电图检测,采集血清检测炎性因子以及血清神经元损伤相关分子的含量。结果：（1）定量脑电图：观察组患者全脑、额叶、颞叶、顶叶、枕叶的（δ＋θ）/（α＋β）比值高于对照组（P〈0.05）;（2）炎性因子：观察组患者血清中肿瘤坏死因子-α（TNF-α）、白介素-1β（IL-1β）、白介素-6（IL-6）、基质金属蛋白酶2（MMP2）、基质金属蛋白酶9（MMP 9）、内皮素（ET）含量高于对照组（P〈0.05）,且与（δ＋θ）/（α＋β）比值呈正相关;（3）神经元损伤相关分子：观察组患者血清中同型半胱氨酸（Hcy）、β-淀粉样蛋白（Aβ）1-4 2、神经微管相关蛋白（Tau）、谷氨酸（Glu）、Asp、甘氨酸（Gly）的含量均高于对照组健康者（P〈0.05）,且与（δ＋θ）/（α＋β）比值呈正相关。结论：阿尔茨海默病患者定量脑电图检测的（δ＋θ）/（α＋β）比值异常升高,且与血清炎性因子以及神经元损伤相关分子的异常具有良好的相关性,是评估阿尔茨海默病严重程度的理想方法。
Objective：To study the quantitative EEG detection results of patients with Alzheimer＇s disease and its correlation with serum index.Methods：A total of 50 cases of Alzheimer＇s disease diagnosed in outpatients of our hospital from 2012 May to 2014 August were enrolled in observation group;healthy people received physical examination during the same period were enrolled in control group.Then quantitative EEG detection was conducted,serum was collected and inflammatory factors,serum neuron injury related molecules were detected.Results：（δ＋θ）/（α＋β）ratio in whole brain,frontal lobe,temporal lobe,parietal lobe,occipital lobe of observation group were higher than those of control group.Serum TNF-α,IL-1β,IL-6,MMP2,MMP9 of observation group were higher than those of control group and positively correlated with（δ＋θ）/（α＋β）ratio.Serum Hcy,Aβ1-4 2,Tau,Glu,Aap,Gly of observation group were higher than those of control group and positively correlated with（δ＋θ）/（α＋β）ratio.Conclusion：Quantitative EEG（δ＋θ）/（α＋β）ratio of patients with Alzheimer＇s disease abnormally increases and has good correlation with serum abnormality of serum inflammatory factors and neuron injury related molecules.It＇s an ideal method to judge the severity of Alzheimer＇s disease.
出处
《海南医学院学报》
CAS
2015年第9期1228-1231,共4页
Journal of Hainan Medical University
基金
辽宁省中医药临床学(专)科能力建设资助项目(2012-Lnzyxzk-04)~~
关键词
阿尔茨海默病
定量脑电图
炎性因子
神经元损伤相关分子
Alzheimer＇s disease Quantitative electroencephalogram Iinflammatory factor Neuron injury related molecules
