摘要
Traditional Chinese medicine(TCM) has played a positive role in the management of hepatocarcinoma. Hepatocarcinoma patients may present Qi-stagnation, damp-heat, blood stasis, Qi-deficiency, Yin-deficiency and other TCM syndromes(Zheng). Modern treatments such as surgery, transarterial chemoembolization(TACE) and high intensity focus ultrasound treatment would influence the manifestation of TCM syndromes. Herbs with traditional efficacy of tonifying Qi, blood and Yin, soothing liver-Qi stagnation, clearing heat and detoxifying and dissolving stasis, have been demonstrated to be potent to prevent hepatocarcinogenesis. TCM has been widely used in all aspects of integrative therapy in hepatocarcinoma, including surgical resection, liver transplantation, TACE, local ablative therapies and even as monotherapy for middle-advanced stage hepatocarcinoma. Clinical practices have confirmed that TCM is effective to alleviate clinical symptoms, improve quality of life and immune function, prevent recurrence and metastasis, delay tumor progression, and prolong survival time in hepatocarcinoma patients. The effective mechanism of TCM against hepatocarcinoma is related to inducing apoptosis, autophagy, anoikis and cell senescence, arresting cell cycle, regulating immune function, inhibiting metastasis and angiogenesis, reversing drug resistance and enhancing effects of chemotherapy. Along with the progress of research in this field, TCM will contribute more to the prevention and treatment of hepatocarcinoma.
Traditional Chinese medicine （TCM） has played apositive role in the management of hepatocarcinoma.Hepatocarcinoma patients may present Qi-stagnation,damp-heat, blood stasis, Qi-deficiency, Yin-deficiency and other TCM syndromes （Zheng）. Modern treatmentssuch as surgery, transarterial chemoembolization （TACE）and high intensity focus ultrasound treatment wouldinfluence the manifestation of TCM syndromes. Herbswith traditional efficacy of tonifying Qi, blood and Yin,soothing liver-Qi stagnation, clearing heat and detoxifyingand dissolving stasis, have been demonstrated to bepotent to prevent hepatocarcinogenesis. TCM hasbeen widely used in all aspects of integrative therapyin hepatocarcinoma, including surgical resection, livertransplantation, TACE, local ablative therapies and evenas monotherapy for middle-advanced stage hepatocarcinoma.Clinical practices have confirmed that TCMis effective to alleviate clinical symptoms, improvequality of life and immune function, prevent recurrenceand metastasis, delay tumor progression, and prolongsurvival time in hepatocarcinoma patients. The effectivemechanism of TCM against hepatocarcinoma is relatedto inducing apoptosis, autophagy, anoikis and cellsenescence, arresting cell cycle, regulating immunefunction, inhibiting metastasis and angiogenesis, reversingdrug resistance and enhancing effects of chemotherapy.Along with the progress of research in this field, TCMwill contribute more to the prevention and treatment ofhepatocarcinoma.
基金
National Natural Science Foundation of China,Nos.81273726 and 81473625
Three-year Action Program of Shanghai Municipality for Traditional Chinese Medicine,No.ZY3-CCCX-3-3025
