摘要
目的:比较研究华佗豆醇提物和水提物镇痛抗炎作用。方法:采用醋酸扭体法和热板法观察华佗豆醇提物和水提物镇痛作用,二甲苯致小鼠耳廓肿胀和小鼠棉球肉芽肿法观察其对小鼠急慢性炎症的影响。结果:华陀豆醇提物各剂量组能减少醋酸引起的小鼠疼痛的扭体次数、提高小鼠的痛阈值、明显抑制二甲苯所致的小鼠耳廓肿胀和小鼠棉球肉芽肿增生(P<0.05,P<0.01)。水提物高剂量能减少醋酸引起的小鼠疼痛的扭体次数、抑制二甲苯所致的小鼠耳廓肿胀和小鼠棉球肉芽肿增生(P<0.05)。结论:华陀豆醇提物和水提物均有镇痛抗炎的作用,且醇提物的镇痛抗炎作用优于水提物的镇痛抗炎作用。
Objective： To compare the anti-inflammatory and analgesic effects of alcohol and aqueous extract of Calonyction muricatum. Methods： Analgesic effect of Calonyction muricatum was studied by mice acetic acid-induced twisting test and hot plate test. Anti-inflammatory effect of Calonyction muricatum was studied by the swelling of mice pinna induced by xylene and the cotton granuloma in mice. Results： Different dose groups of alcohol extract of Calonyction muricatum could reduce the pain twisting times in mice and increase the pain thresholds in mice （P〈0.05, P〈0.01）. It could inhibit the swelling of mice pinna induced by xylene and the cotton granuloma in mice （P〈0.05, P〈0.01）. High dose group of aqueous extract of Calonyction muricatum could reduce the twisting times in mice. It could inhibit the swelling of mice pinna induced by xylene and the cotton granuloma in mice （P〈0.05）. Conclusion： The alcohol and aqueous extracts of Calonyction muricatum had analgesic and anti- inflammatory effects, and alcohol extract were better than aqueous extract on analgesic and anti-inflammatory effects.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2015年第8期2980-2982,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家科技部"十二五"国家科技支撑计划课题(No.2013BAI11B06)
广西科技厅重大专项课题(No.1355001-4-1)
广西科学研究与技术开发计划项目(No.桂科攻1298003-5)
广西卫生厅中医药科技专项课题(No.GZZY13-11)~~
关键词
华佗豆
镇痛
抗炎
比较研究
Calonyction muricatum
Analgesic
Anti-inflammatory
Comparative study
