摘要
目的探讨甲状腺结节与胰岛素抵抗的相关性。方法深圳南山区健康体检者3460例，根据超声检查结果统计甲状腺结节发生率，分析其与胰岛素抵抗的关系。结果本组甲状腺结节发生率为44．8％；女性甲状腺结节发生率（51．6％）高于男性（36．4%）（P〈0．01）；甲状腺结节组体质量指数（bodymassindex，BMI）[（25．7±2．6）kg／m2]、收缩压[（134±22）mmHg]、空腹血糖[（5．9±1．4）mmol／L]、稳态模型评估胰岛素抵抗指数（homeostasis model of assessment for insulinresistanceindex,HOMA-IR）（3．4±1．8）明显高于非结节组[（23．5±2．8）kg／m2、（128±12）mmHg、（5．0±1．1）mmol／L、2．6±1．4]（P〈0．05）；logistic回归分析显示甲状腺结节与空腹血糖（OR=1．145，95％CI：1．062-1．249，P=0．001）、BMI（OR=1．227，95％CI：1．128-1．326，P=0．002）呈正相关；甲状腺结节发生率随HOMA—IR增长而增高。结论深圳南山区居民甲状腺结节发生率较高；甲状腺结节与胰岛素抵抗具有相关性，肥胖及高血糖是甲状腺结节的危险因素。
Objective To explore the correlation between thyroid nodule and insulin resistance. Methods A cross- sectional survey was done in 3 460 health volunteers in Nanshan district, Shenzhen. The prevalence of thyroid nodule was calculated according to the examination results and the correlation between thyroid nodule and insulin resistance was analyzed. Results The prevalence of thyroid nodule was 44.8%, and was significantly higher in females （51.6%） than that in males （36.4%） （P〈0.01）. The body mass index （（25.7±2.6） kg/m2）, systolic blood pressure （（134±22） mm Hg）, fasting plasma glucose （（5.9 ±1.4） mmol/L） and homeostasis model of assessment for insulin resistenee index （HOMA-IR） （3. 4±1. 8） were significantly higher in thyroid nodule group than those in no-thyroid nodule group （（23.5±2.8） kg/m2 , （128±12） mm Hg, （5.0± 1.1） mmol/L, 2.6± 1.4） （P〈0.05）. Logistic regression analysis revealed that thyroid nodule was positively correlated with fasting plasma glucose （OR= 1. 145, 95%CI： 1. 062 to 1. 249, P=0.001） and body mass index （OR=I.227, 95%CI： 1.128 to 1.326, P=0.002）. The prevalence of thyroid nodule increased with the increase of HOMA-IR. Conclusion The prevalence of thyroid nodule is high among the residents in Nanshan district, Shenzhen. Thyroid nodule is positively correlated with insulin resistance. Obesity and high plasma glucose are the risk factors for thyroid nodule.
出处
《中华实用诊断与治疗杂志》
2015年第8期779-781,共3页
Journal of Chinese Practical Diagnosis and Therapy
