摘要
目的通过分析结缔组织病相关性间质性肺疾病（connectivetissuediseaseandinterstitiallungdisease，CTD—ILD）患者的各项临床资料，以期提高临床医师对该组疾病的了解与认识。方法收集并回顾性分析2013年6月1日～2014年6月30日于温州医科大学附属第一医院风湿免疫科住院的138例CTD—ILD患者的一般情况、临床表现、实验室检查、血气分析、肺功能、肺部高分辨率CT（highresolutioncomputedtomography，HRCT）等临床资料。结果CTD—ILD患者138例，其中，男性32例，女性106例，患者年龄26—79岁，平均年龄56．00±12．12岁。呼吸系统症状发生率高于全身症状，全身症状发生率高于皮肤表现、眼干口干等。93例患者进行血气分析检查，其中低氧血症36例，I型呼吸衰竭5例，Ⅱ型呼吸衰竭0例。68例患者进行肺功能检查，其中限制性通气功能障碍47例，混合性通气功能障碍1例，弥散功能障碍65例。CTD—ILD的HRCT表现多为磨玻璃影、网格影、蜂窝影、实变影、结节影等。结论CTD—ILD患者好发于女性，肺部病变症状可首发于CTD症状之前，并可独立进展，因此在发现间质性肺病时应注意继发于结缔组织病的可能，早期筛查血气分析、肺功能及肺部HRCT有利于CTD—ILD的诊断及治疗方案制定。
Objective To strengthen the clinician＇s understanding and knowledge of connective tissue disease（CTD） combined with interstitial lung disease（ILD） by analyzing the clinical data of CTD - ILD. Methods The clinical data of the 138 patients with CTD - ILD, hospitalized at rheumatology department in the First Affiliated Hospital of Wenzhou Medical University from June 1, 2013 to June 30, 2014, including the general situation,clinical manifestations, laboratory tests, blood gas analysis, pulmonary function, and lung high resolution computed tomography（HRCT） and so on were collected. Results There were 138 patients with CTD - ILD, of whom 32 pa- tients were male and 106 were female. The age ranged from 26 to 79 years old and the average was 56.00 ± 12.12 years old. The inci- dence of respiratory symptoms was higher than that of systemic symptoms, and the incidence of systemic symptoms was highter than skin manifestations, dry eyes, dry mouth and so on. Among 93 cases of patients who received blood gas analysis, hypoxemia in 36 cases, I - type respiratory failure in 5 cases, type II respiratory failure in 0 cases. Among 68 cases of patients who received pulmonary function tests, restrictive ventilatory dysfunction in 47 cases, mixed ventilatory dysfunction in 1 case, diffuse dysfunction in 65 cases. The HRCT manifestation of CTD - ILD was ground - glass opacity, mesh shadow, cellular shadow, consolidation, nodules shadow and so on. Conclusion CTD - ILD mainly occurred in female. The occurrence of some lung diseases was earlier than that of CTD symptoms, and can be independent. Therefore, when founding interstitial lung disease we should pay attention to possible secondary to connective tissue disease. Early screening for blood gas analysis, pulmonary function and lung HRCT is helpful for diagnosis and treatment plan formulation of CTD - ILD.
出处
《医学研究杂志》
2015年第8期108-112,共5页
Journal of Medical Research
关键词
结缔组织病
间质性肺疾病
临床表现
肺部高分辨率CT
Connective tissue disease
Interstitial lung disease
Clinical manifestations
Lung high resolution computed tomography
