摘要
间充质干细胞(mesenchymal stem cells,MSCs)不仅具有多分化潜能,还具有免疫调节功能.MSCs因具有主动趋向炎性或肿瘤组织、抗炎、可塑性、无免疫排斥、易于分离以及便于外源基因转染和表达等优点而被广泛用于消化系统疾病的研究.本文阐述了MSCs在腐蚀性食管损伤、反流性食管炎、胃溃疡、放射性肠损伤、重症急性胰腺炎、炎症性肠病、非酒精性脂肪性肝炎、急性肝衰竭、肝纤维化、自身免疫性肝病、肝硬化、食管癌、胃癌、结肠癌、肝癌以及胰腺癌等消化系统疾病治疗中的最新应用进展.
Mesenchymal stem cells（MSCs） have the capacity of multipotent differentiation and the property of immunomodulation.MSCs have been widely used in digestive system disease research because of their advantageous characteristics such as homing to areas of inflammation or tumour tissue,anti-inflammation,high plasticity,absence of immunologic rejection,being easy to be isolated,and being convenient for theexpression of exogenous genes.In this article,we will review the application of mesenchymal stem cells in digestive system diseases including caustic esophagus injury,reflux esophagitis,gastric ulcer,radioactive intestinal injury,severe acute pancreatitis,inflammatory bowel disease,nonalcoholic steatohepatitis,acute liver failure,hepatic fibrosis,autoimmune liver diseases,liver cirrhosis,esophageal cancer,gastric cancer,colon cancer,liver cancer,and pancreatic cancer.
出处
《世界华人消化杂志》
CAS
2015年第17期2688-2696,共9页
World Chinese Journal of Digestology
关键词
间充质干细胞
食管疾病
胃溃疡
重症急性胰腺炎
炎症性肠病
肝病
消化系肿瘤
治疗
Mesenchymal stem cells
Esophageal diseases
Gastric ulcer
Severe acute pancreatitis
Inflammatory bowel disease
Liver diseases
Gastrointestinal tumors
Therapy
