摘要
目的分析糖尿病肾病腹膜透析(PD)病人的临床现状,以采取有效措施减少并发症,提高病人生存质量。方法选取接受PD治疗3个月以上的病人36例,其中非糖尿病组病人22例,糖尿病组病人14例。以主观综合性营养评估法(SGA)及血总蛋白(TP)、清蛋白(Alb)、前清蛋白(PA)等指标对两组进行营养状况评估;采用酶联免疫吸附试验(ELISA)方法检测血清超敏C反应蛋白(Hs-CRP),进行微炎症状态评估;以下肢水肿程度评价两组病人的容量负荷;检测两组病人血红蛋白(Hb)、血肌酐(Scr)、尿素氮(BUN)等生化指标;比较两组病人过去1年内腹膜炎发生率。结果两组营养不良发生率和Alb、PA水平比较差异有显著性(χ2=6.44,t=2.12、2.66,P<0.05)。糖尿病组血清Hs-CRP水平高于非糖尿病组(t=2.13,P<0.05)。两组水肿程度差异有显著性(χ2=5.68,P<0.05)。糖尿病组腹膜炎年发生率明显高于非糖尿病组(χ2=9.88,P<0.05)。结论糖尿病PD病人较非糖尿病者更易出现营养不良、高容量负荷、感染和微炎症等并发症,应采取针对性防治措施减少并发症。
Objective To analyze the status quo of patients with diabetic nephropathy（DN）undergoing peritoneal dialysis（PD）,decrease complications and improve their quality of life. Methods Thirty-six patients-22 in non-diabetic group,and14 in diabetic group-received PD for more than three months were enrolled in this study.Applying subjective global assessment（SGA）,total protein（TP）,serum albumin（Slb）,prealbumin（PA）,and nutritional status of patients in both groups were assessed.Using enzyme-linked immunoassay（ELISA）to detect serum high sensitivity C-reactive protein（Hs-CRP）for evaluation of micro-inflammatory state.The edema of legs was recorded to estimate the volume load of the patients.The biomarkers such as hemoglobin（Hb）,serum creatinine（Scr）,blood urea nitrogen（BUN）,and others were measured.The incidence of peritonitis in the past one year in patients between the two groups was compared. Results The differences of SGA,Alb,and PA between the two groups were statistically significant（χ^2=6.44;t=2.12,2.66;P〈0.05）.Compared with the non-diabetic group,the level of HsCRP in the diabetic group was higher（t=2.13,P〈0.05）.The difference of the degree of edema between patients in the two groups was significant（χ^2=5.68,P〈0.05）.The annual incidence of peritonitis in the diabetic group was higher than that in the non-diabetic（χ^2=9.88,P〈0.05）. Conclusion Complications like malnutrition,high volume loading,infections and micro-inflammation are more prone to appear in diabetic patients who receive peritoneal dialysis than non-diabetic ones,preventive and curative measures targeting the complications should be conducted.
出处
《齐鲁医学杂志》
2015年第4期476-477,480,共3页
Medical Journal of Qilu
关键词
腹膜透析
糖尿病
营养不良
贫血
感染
peritoneal dialysis
diabetes mellitus
malnutrition
anemia
infection
