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脑源性神经营养因子在突触可塑性中的作用 被引量：21

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摘要 脑源性神经营养因子(BDNF)作为神经营养因子家族中重要的一员,参与神经元的生长、发育、分化和维持。其在大脑中以前体蛋白和成熟体的形式表达,通过与神经细胞膜上不同的受体结合,激活多种信号通路引起突触的形态结构及长时程增强和长时程抑制的改变,从而对突触可塑性进行调节,对于改善学习记忆功能具有显著的疗效,已成为近年来神经科学和神经精神科学领域研究的重点内容。本文就BDNF的生物学特性和在突触可塑性中的作用做一综述。
作者 刘志娟 吕佩源
机构地区 河北医科大学研究生学院 河北省人民医院神经内科
出处 《国际神经病学神经外科学杂志》 北大核心 2015年第2期185-188,共4页 Journal of International Neurology and Neurosurgery
基金 河北省自然科学基金(H2013307046) 河北省重大医学科研课题项目(zd2013005)
关键词 脑源性神经营养因子 突触可塑性 长时程增强 长时程抑制
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献30

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二级参考文献20

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国际神经病学神经外科学杂志
2015年 第2期

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