摘要
目的研究低分子量肝素(LMWH)联合乌司他丁治疗重症急性胰腺炎的疗效。方法 280例重症急性胰腺炎患者随机分为两组:对照组(n=140)给予乌司他丁及常规治疗;观察组(n=140)除乌司他丁及常规治疗外同时使用LMWH治疗,疗程2周。观察两组患者临床参数、实验室检验指标以及CT胰腺炎坏死分值(CT score of pancreatic necrosis,CTSPN)(Balthazar CT)变化。结果入院时,两组患者的临床表现、实验室参数以及CTSPN差异无统计学意义(P>0.05);治疗后,观察组患者临床表现和实验室检验指标较对照组患者显著改善(P<0.05或<0.01),观察组急性生理和慢性健康评估Ⅱ(Acute Physiology and Chronic Health EvaluationⅡ,APACHEⅡ)分值、并发症发生率、病死率及平均住院时间显著低于对照组(P<0.05或<0.01)。观察组CTSPN显著低于对照组(P<0.05)。观察组无任何血液并发症发生。结论 LMWH联合乌司他丁能够增强传统治疗方式治疗重症急性胰腺炎的疗效,能够显著降低重症急性胰腺炎的病死率。
Objective To observe the effect of low molecular mass heparin（LMWH）combined with ulinastatin in the treatment of severe acute pancreatitis.Methods A total of 280 patients with acute pancreatitis were randomly divided into two groups,including control group with ulinastatin and conventional treatment（n=140）and observation group with LMWH combined with ulinastatin and conventional treatment（n =140）.After two weeks of treatment,changes in clinical parameters,laboratory indicators and CT score of pancreatic necrosis（CTSPN）were observed.Results There were no significant difference between two groups in clinical and laboratory parameters and CTSPN at baseline（P 〉0.05）.After treatment,the clinical manifestations and laboratory indicators were significantly improved,and Acute Physiology and Chronic Health EvaluationⅡ（APACHEⅡ）score,complication rate,death rate and average hospitalization time were significantly lower in observation group than in control group（P〈0.05or0.01）.The CT SPN score in observation group was significantly lower than that of control group（P〈0.05）.The blood complications were not found in observation group.Conclusion LMWH combined with ulinastatin can enhance the therapeutic effect of traditional methods in treating severe acute pancreatitis,which can significantly reduce the mortality of severe acute pancreatitis.
出处
《临床荟萃》
CAS
2015年第7期799-802,共4页
Clinical Focus
关键词
胰腺炎
急性坏死性
肝素
低分子量
乌司他丁
pancreatitis
acute necrotizing
heparin
low-molecular-meight
ulinastatin
