摘要
目的探讨瑞芬太尼联合七氟烷麻醉对术后患者认知功能的影响。方法 86例择期行腹腔镜手术的女性患者根据麻醉方法分为观察组和对照组,每组43例。对照组患者给予瑞芬太尼麻醉,观察组患者给予瑞芬太尼联合七氟烷麻醉;比较2组患者的生命体征、苏醒时间及认知功能。结果麻醉前、麻醉1 h、麻醉2 h及麻醉结束时2组患者的收缩压、舒张压、心率、呼吸频率及动脉血氧饱和度比较差异均无统计学意义(P>0.05)。观察组和对照组患者苏醒时间分别为(12.6±3.4)、(28.4±2.5)min,观察组患者苏醒时间显著短于对照组(P<0.05)。2组患者麻醉前简易精神状态量表(MMSE)评分比较差异无统计学意义(P>0.05);麻醉结束后6、12 h,观察组患者MMSE评分显著高于对照组(P<0.05);麻醉结束后24 h,2组患者MMSE评分比较差异无统计学意义(P>0.05)。麻醉前2组患者词语记忆能力、简单计算能力及图片再认能力评分比较差异无统计学意义(P>0.05);2组患者麻醉结束后12 h图片再认能力评分与麻醉前比较差异无统计学意义(P>0.05);2组患者麻醉结束后12 h词语记忆能力、简单计算能力评分均低于麻醉前(P<0.05);麻醉结束后12 h,观察组患者词语记忆能力和简单计算能力评分显著高于对照组(P<0.05)。结论瑞芬太尼联合七氟烷麻醉可显著改善患者术后认知功能。
Objective To study the effect of remifentanil combined with sevoflurane anesthesia on cognitive function of patients after operation. Methods Eighty-six female patients who underwent laparoscopic operation were divided into observation group and control group,forty-three cases in each group. The patients in control group were anesthetized with remifentanil,and the patients in observation group were anesthetized with remifentanil and sevoflurane. The vital sign,palinesthesia time and cognitive function were compared between the two groups. Results There was no significant difference in systolic blood pressure,diastolic blood pressure,heart rate,respiration rate and pulse oxygen saturation at the time points of preanesthesia,beginning of anesthesia for one and two hours,and the end of anesthesia between the two groups（ P〉0. 05）. The palinesthesia time in observation group and control group was（12. 6 ± 3. 4） and（28. 4 ± 2. 5） min,respectively. The palinesthesia time in observation group was significantly shorter than that in control group（ P〈0. 05）. There was no significant difference in mini-mental state examination（ MMSE） score before anesthesia between the two groups（ P〉0. 05）. Six and twelve hours after anesthesia,the MMSE score in observation group was significantly higher than that in control group（ P〈0. 05）. Twenty-four hours after anesthesia,there was no significant difference in MMSE score between the two groups（ P〉0. 05）. There was no significant difference in the scores of term memory,simple calculation and picture recognition before anesthesia between the two groups（P〈0. 05）. There was no significant difference in the score of picture recognition before anesthesia and twelve hours after anesthesia in the two groups（ P〈0. 05）. Compared with preanesthesia,the scores of term memory and simple calculation decreased twelve hours after anesthesia in the two groups（ P〈0. 05）. Twelve hours after anesthesia,the scores of term memory and simple calculation in observation group were significantly higher than those in control group（ P〈0. 05）. Conclusion Remifentanil combined with sevoflurane anesthesia can significantly improve the cognitive function of patients after operation.
出处
《新乡医学院学报》
CAS
2015年第6期537-539,共3页
Journal of Xinxiang Medical University
关键词
瑞芬太尼
七氟烷
麻醉
认知功能
remifentanil
sevoflurane
anesthesia
cognitive function
