摘要
目的:探讨糖尿病肾病(DN)患者中医证型与甲状腺激素水平的相关性。方法:收集2011年1月至2013年12月山东省中医药大学第二附属医院肾病内科收治的DN患者164例,根据中医辨证分为本证5型:阴虚燥热型18例、肝肾阴虚型24例、气阴两虚型55例、脾肾气虚(或阳虚)型32例、阴阳两虚型35例;标证3型:湿浊证41例、血瘀证51例、痰瘀证33例;另选同期单纯糖尿病患者21例作为对照组。比较分析DN本证、标证及对照组患者间的甲状腺激素水平。结果:本证中阴虚燥热型T3、FT3、T4、FT4均明显高于对照组,TSH低于对照组(P<0.05);肝肾阴虚型、气阴两虚型、脾肾气虚(阳虚)型、阴阳两虚型T3、FT3、T4、FT4明显低于对照组,TSH高于对照组(P<0.05);不同证型T3、FT3、T4、FT4水平依次为阴阳两虚型<脾肾气虚(阳虚)型<气阴两虚型<肝肾阴虚型(P<0.05)。湿浊证、血瘀证、痰瘀证T3、FT3、T4、FT4均低于对照组(P<0.05),TSH高于对照组(P<0.05))。结论:甲状腺激素水平与DN的中医证型密切关系,可作为反映DN进展和转归的客观指标。
Objective：To explore the relativity between TCM patterns of diabetic nephropathy （DN） and the level of thyroid hormone. Methods： Altogether 164 DN patients admitted to nephrology department of Shandong Provincial Hospital of Integrative Medicine were collected from January, 2011 to December, 2013, according to syndrome differentiation, they were grouped into five kinds of the root causes： 18 cases of Yin-deficiency and dryness-heat pattern, 24 cases of liver-kidney Yin-deficiency pattern, 55 cases of Qi-Yin dual deficiency pattern, 32 cases of spleen-kidney Qi-deficiency （Yang-deficiency） pattern, 35 cases of Yin-Yang dual deficiency pattern;three types of the branch causes：41 cases of dampness-turbidity pattern, 51 cases of blood stasis pattern and 33 cases of phlegm stasis pattern;meanwhile, 21 patients with diabetes mellitus were selected as the control group. The levels of thyroid hormone in the groups were compared. Results：The levels of T3, FT3, T4 and FT4 in Yin-deficiency and dryness-heat pattern of the root causes were higher than these of the control group notably, the level of TSH was lower than that of the control group obviously （P〈0.05）; the levels of T3, FT3, T4 and FT4 in the patients of liver-kidney Yin-deficiency pattern, Qi-Yin dual deficiency pattern, spleen-kidney Qi-deficiency （Yang-deficiency） pattern, Yin-Yang dual deficiency pattern were lower than these of the control group evidently, TSH level was higher than that of the control group notably （P〈0.05）;the levels of T3, FT3, T4 and FT4 in different patterns were in the order：Yin-Yang dual deficiency pattern〈spleen-kidney Qi-deficiency （Yang-deficiency） pattern〈Qi-Yin dual deficiency pattern〈liver-kidney Yin-deficiency pattern（P〈0.05）. The levels of T3, FT3, T4 and FT4 in the patients of dampness-turbidity pattern, blood stasis pattern and phlegm stasis pattern were lower than these of the control group clearly（P〈0.05）, TSH level was higher than the control group remarkably （P〈0.05）. Conclusion：The level of thyroid hormone is closely related to TCM patterns of DN, and it could be used as an objective index of reflecting the development and consequence of DN.
出处
《西部中医药》
2015年第5期89-91,共3页
Western Journal of Traditional Chinese Medicine
关键词
糖尿病肾病
甲状腺激素
中医证型
diabetic nephropathy
thyroid hormone
TCM patterns
