摘要
目的：研究西拉普利与氨氯地平对原发性高血压患者QT间期离散度与心律失常的疗效。方法：2011年3月-2014年3月我院收治的120例原发性高血压合并室性心律失常的患者被纳入研究对象,随机均分为西拉普利组和氨氯地平组,两组均接受常规降压治疗,比较两组的血压、QT间期以及心律失常情况。结果：与氨氯地平组比较,西拉普利组患者的24h平均收缩压[（123.81±17.95）mmHg比（104.92±14.25）mmHg]、舒张压[（88.31±10.28）mmHg比（72.24±8.45）mmHg],24h平均收缩压变异度[（11.62±1.34）mmHg比（7.34±0.97）mmHg]、舒张压变异度[（9.47±1.18）mmHg比（5.13±0.72）mmHg],QT间期[（385.1±50.4）ms比（342.7±48.5）ms]、校正QT间期[（362.7±50.2）ms比（321.8±45.1）ms]、QT间期离散度[（34.1±5.1）ms比（22.5±3.7）ms]均明显降低（P〈0.05或〈0.01）;室性心律失常分级明显优于氨氯地平组（P〈0.05）。结论：对于高血压并发心律失常病人西拉普利治疗较氨氯地平降低血压,QT间期离散度和改善室性心律失常的疗效更好。
Objective：To study therapeutic effect of cilazapril and amlodipine on QT interval dispersion and arrhyth-mia in patients with essential hypertension （EH） .Methods：A total of 120 EH patients complicated with ventricular arrhythmia in our hospital from Mar 2011 to Mar 2014 were enrolled ,randomly and equally divided into cilazapril group and amlodipine group ,the two groups all received routine antihypertensive therapy .Blood pressure ,QT in-terval and arrhythmias were compared between two groups .Results：Compared with amlodipine group ,there were significant reductions in 24h mean systolic blood pressure [24hSBP ,（123.81 ± 17.95） mmHg vs .（104.92 ± 14.25） mmHg] ,24h mean diastolic blood pressure [24hDBP ,（88.31 ± 10.28） mmHg vs .（72.24 ± 8.45） mmHg] ,24hSBP variability [ （11.62 ± 1.34） mmHg vs .（7.34 ± 0.97） mmHg] ,24hDBP variability [ （9.47 ± 1.18） mmHg vs .（5.13 ± 0.72） mmHg] ,QT interval [ （385.1 ± 50.4） ms vs .（342.7 ± 48.5） ms] ,corrected QT interval [ （362.7 ± 50.2） ms vs .（321.8 ± 45.1） ms] and QT interval dispersion [ （34.1 ± 5.1） ms vs .（22.5 ± 3.7） ms] in cilazapril group , P〈0.05 or 〈0.01;ventricular arrhythmia class in cilazapril group was significantly better than that of amlodipine group , P〈0. 05. Conclusion：Therapeutic effect of cilazapril is more helpful to reduce blood pressure ,QT interval dispersion and improve ventricular arrhythmia than amlodipine in EH patients complicated with arrhythmia .
出处
《心血管康复医学杂志》
CAS
2015年第3期319-322,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
