摘要
目的 通过分析围产期孕妇生殖道B族链球菌（GBS）的感染和耐药性及不良妊娠结局,为临床医师制定有效的预防和治疗措施提供依据.方法 2013年1月至2015年2月,对795例围产期孕妇生殖道分泌物进行GBS培养鉴定与药敏试验,并观察临床症状及不良妊娠结局,对结果进行统计学分析.结果 795例孕妇中共检出GBS携带者256例,带菌率为32.2％.＜30岁组（28.9％）与≥30岁组（42.3％）的带菌率差异具有统计学意义（x2=19.095,P＜0.01）.GBS阳性者与GBS阴性者的临床症状发生率（18.8％ vs 8.0％）差异具有统计学意义（x 2=39.514,P＜ 0.01）.10种抗菌药物（万古霉素、利奈唑胺、青霉素、氨苄西林、头孢曲松、呋喃妥因、左氧氟沙星、克林霉素、红霉素及四环素）耐药率分别为：0％、0％、0.6％、3.1％、6.6％、9.6％、21.9％、23.8％、29.9％及58.1％.D-抑菌圈试验阳性率为23.9％.GBS阳性组与GBS阴性组比较,胎膜早破、早产、宫内感染及新生儿感染发生率的差异均有统计学意义（P＜0.01）.结论 该区围产期孕妇GBS带菌率较高,且高龄者易于感染;围产期孕妇感染GBS可增加不良妊娠结局的发生,应据药敏试验结果选择敏感性抗生素予以临床干预.
Objective To provide some prevention and treatment references for clinicians analyzing drug resistance and adverse pregnancy outcomes of perinatal pregnant women whose reproductive tracts were infected by group B streptococci （GBS）.Methods From January 2013 to February 2015,the vaginal secretions sampled from 795 perinatal pregnant women were cultured to test GBS.The drug sensitivity was tested.The clinical symptoms and adverse pregnancy outcomes were observed.The results were statistically analyzed.Results Among the 795 pregnant women,256 carried GBS,with a rate of 32.2%.The GBS-carried rate was 28.9% in the group whose age 〈30 years and was 42.3% in the group whose age 〉30 years,with a statistical difference （x 2=19.095,P〈0.01）.There was a statistical difference in the incidence of clinical symptoms between the GBS-postive and-negative patients（18.8% vs.8.0%,x 2=39.514（P〈0.01）.The antimicrobial resistant rates of ten kinds of antibacterial drugs,vancomycin,linezolid,penicillin,ampicillin,ceftriaxone,nitrofurantoin,levofloxacin,clindamycin-erythromycin,and tetracycline,were 0.0%,0.0%,0.6%,3.1%,6.6%,9.6%,21.9%,23.8%,29.9%,and 58.1%,respectively.The positive rate of D-bacteriostatic ring experiment was 23.9%.There were statistical differences in the incidences of premature rupture of membranes,preterm delivery,intrauterine infection,and neonatal infection between the GBS-positive and-negative patients （P〈0.01）.Conclusions The GBS-carried rate is high in perinatal pregnant women,especially in the older ones,in the region.The incidence of adverse pregnancy outcomes can be increased by the GBS infections in perinatal pregnant women.Sensitive antibiotic should be used basing on the results of drug susceptibility test.
出处
《国际医药卫生导报》
2015年第11期1526-1529,共4页
International Medicine and Health Guidance News
关键词
B族链球菌
围产期孕妇
带菌率
药敏试验
不良妊娠结局
Group B streptococci （GBS）
Perinatal pregnant women
GBS-carried rate
Chemosensitivity testing
Adverse pregnancy outcomes
