摘要
目的:探讨中西医结合治疗小儿支气管哮喘的临床疗效。方法:按照随机数字表法将收治的支气管哮喘患儿随机分为研究组和对照组,其中研究组采用中西医结合治疗,而对照组则单纯给予西医治疗,比较两组患儿治疗前后的临床症状评分、实验室指标及肺功能的变化。结果:研究组患儿中临床痊愈13例,占30.95%,显效15例,占35.71%,有效10例,占23.81%,总有效率达90.48%;经统计分析发现研究组的总有效率(90.48%)明显高于对照组(69.05%),且差异具有统计学意义(χ2=5.97,P<0.05)。在治疗后,研究组患者在咳嗽、喘息两个临床症状方面的临床治愈率明显高于对照组,且差异具有统计学意义(χ2=4.02、3.98,P<0.05)。研究组患者在治疗后IL-12较治疗前明显升高,而IL-4、Ig E等实验室指标则较治疗前明显下降,且差异具有统计学意义(t=6.55、5.87、5.14,P<0.05)。另外,研究组治疗后上述实验室指标与对照组治疗后比较亦存在显著差异,且差异具有统计学意义(t=4.85、4.02、3.88,P<0.05)。研究组患者在治疗后FEV1、FEV1/FVC、PEF%等肺功能指标较治疗前明显升高,且差异具有统计学意义(t=4.11、5.61、4.35,P<0.05)。另外,研究组治疗后上述肺功能指标高于对照组治疗后相应的肺功能指标,但是差异无统计学意义(P>0.05)。结论:在治疗小儿支气管哮喘时采用中西医结合治疗方法可以明显改善患儿的临床症状,提高临床治愈率,值得临床推广。
Objective ： To investigate the clinical effect of combined traditional Chinese and Western medicine treatment of children with bronchial asthma. Methods ： The bronchial asthma children were randomly divided into study group and control group. The study group was treated by combined western and Chinese medicine while the control group was only treated with western medicine therapy. Before and after treatment, the two groups were compared the clinical symptoms, la- boratory indicators and pulmonary function changes. Results：The clinical research groups cured 13 cases, accounting for 30.95 % , effective in 15 cases, accounting for 35.71% , effective in 10 cases, accounting for 23.81%, the total effective rate was 90.48% ; statistical analysis found that efficiency of total research group （ 90.48% ） was significantly higher than that of the control group （69.05 % ）, and the differences were statistically significant （ χ2 = 5.97, P 〈 0.05 ）. After treatment, clinical research groups in coughing, wheezing and two clinical cure rate were significantly higher than those of the control group, and the difference was statistically significant （ χ2 = 4.02,3.98, P 〈 0.05 ）. The study group patients in IL- 12 after treatment was significantly increased than before treatment, while IL -4, IgE and other laboratory indexes were significantly decreased than before treatment, and the difference had statistical significance （t = 6. 55,5.87,5.14 ,P 〈 0.05）. In addition, the study group after treatment, the laboratory index compared with the control group after treat- ment, there were significant differences, and the difference had statistical significance （ t = 4.85,4.02,3.88, P 〈 0.05 ）. Lung function indices in patients with research groups in the treatment of FEV1, FEV1 / FVC and PEF% were signifi- cantly increased after treatment, and the difference had statistical significance （t =4.11,5.61,4.35 ,P 〈 0.05）. In addi- tion, the study group after treatment, the lung function index was higher than that of pulmonary function index of the corre- sponding control group after treatment, but the difference was not statistically significant （ P 〈 0. 05 ）. Conclusion ： The clin- ical symptoms in the treatment of children with bronchial asthma by combination of Chinese traditional and Western medi- cine treatment can obviously improve the clinical cure rate and clinical symptoms in children. It is worth the clinical pro-motion.
出处
《中华中医药学刊》
CAS
北大核心
2015年第6期1464-1467,共4页
Chinese Archives of Traditional Chinese Medicine
关键词
中西医结合
儿童
支气管哮喘
combining traditional Chinese and Western medicine
children
bronchial asthma
