摘要
研究了一种以2,4-二氯-5-甲氧基嘧啶、环丙胺为起始原料,经脱氯、钯催化交叉偶联二步反应合成新型有机医药中间体5-甲氧基-2-环丙胺基嘧啶的工艺,总收率约为63%。分析探讨了反应机理和影响因素,产品结构经~1H NMR、MS表征确认。
Found a synthesis process of N-cyclopropyl-5-methoxypyrimidin-2-amine（a new organic pharmaceutical intermediates） with the original material of 2,4-dichloro-5-oxo-methylpyrimidine and eyclopropylamine through two steps of chemical reaction by dechlorination and palladium-catalyzed cross-coupling. Total yield of the reaction is 63 %. Reaction mechanism and the impact factors were discussed. The structure of the products were characterized by 1H NMR. MS spectra.
出处
《计算机与应用化学》
CAS
2015年第5期572-574,共3页
Computers and Applied Chemistry
基金
杭州市属高校绿色精细化工研究与技术转化重点实验室资助项目(HZJ2012-02)
关键词
5-甲氧基-2-环丙胺基嘧啶
钯催化
交叉偶联
合成
N-cyelopropyl-5-methoxypyrimidin-2-amine
Palladium-catalyzed
cross-coupling
synthesis process
